Joanna J Hurley

TL;DR: This review examines the current understanding of the molecular genetics of colorectal carcinogenesis and concludes that gastroenterologists have a working knowledge of the pathological mechanisms that drive the disease.

TL;DR: One of the most striking features of the data in adult CD is the increasing frequency of abdominal pain and bloating in the female cohort, which is likely to result in a wider spectrum of individuals with nonspecific gastrointestinal symptoms being investigated and diagnosed with CD in the future.

TL;DR: It is expected that identification of the missing heritable component of CRC will be resolved through evermore comprehensive cataloguing and phenotypic annotation of CRC-associated variants identified through sequencing approaches, which will have important clinical implications, particularly in areas such as risk stratification, public health and CRC prevention.

TL;DR: Chloeendoscopy improved the diagnostic yield of anomas in MAP and FAP 3-fold, and in both MAP andFAP this resulted in a clinically significant upstaging in Spigelman score, and further studies are required to determine the impact of improved adenoma detection on the management and outcome of duodenal polyposis.

TL;DR: The significantly higher burden of somatic mutations in MAP than FAP duodenal adenomas despite lower Spigelman stage disease could increase cancer risk in the context of apparently less severe benign disease.