J
Joaquim M. Vieira
Researcher at University of Oxford
Publications - 41
Citations - 3757
Joaquim M. Vieira is an academic researcher from University of Oxford. The author has contributed to research in topics: Vascular endothelial growth factor A & Lymphatic system. The author has an hindex of 22, co-authored 39 publications receiving 3079 citations. Previous affiliations of Joaquim M. Vieira include UCL Institute of Child Health & British Heart Foundation.
Papers
More filters
Journal ArticleDOI
Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction
Alessandro Fantin,Joaquim M. Vieira,Gaia Gestri,Laura Denti,Quenten Schwarz,Sergey V. Prykhozhij,Francesca Peri,Stephen W. Wilson,Christiana Ruhrberg +8 more
TL;DR: It is shown that tissue macrophages promote tip cell fusion downstream of VEGF-mediated tip cell induction, and that they could equally well be exploited to stimulate tissue vascularization in ischemic disease.
Journal ArticleDOI
De novo cardiomyocytes from within the activated adult heart after injury
Nicola Smart,Sveva Bollini,Karina N. Dubé,Joaquim M. Vieira,Bin Zhou,Bin Zhou,Bin Zhou,Sean M. Davidson,Derek M. Yellon,Johannes Riegler,Anthony N. Price,Mark F. Lythgoe,William T. Pu,William T. Pu,Paul R. Riley +14 more
TL;DR: It is demonstrated in mice that the adult heart contains a resident stem or progenitor cell population, which has the potential to contribute bona fide terminally differentiated cardiomyocytes after myocardial infarction and is shown to structurally and functionally integrate with resident muscle.
Journal ArticleDOI
Cardiac lymphatics are heterogeneous in origin and respond to injury
Linda Klotz,Sophie Norman,Joaquim M. Vieira,Megan Masters,Mala Rohling,Karina N. Dubé,Sveva Bollini,Fumio Matsuzaki,Carolyn A. Carr,Paul R. Riley +9 more
TL;DR: Cardiac lymphatic vessels in mice have a heterogeneous cellular origin, whereby formation of at least part of the cardiac lymphatic network is independent of sprouting from veins, and it is suggested that lymphangiogenesis may represent a therapeutic target to promote cardiac repair following injury.
Journal ArticleDOI
Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair
Filipa C. Simões,Thomas J. Cahill,Amy Kenyon,Daria Gavriouchkina,Daria Gavriouchkina,Joaquim M. Vieira,Xin Sun,Daniela Pezzolla,Christophe Ravaud,Eva Masmanian,Michael Weinberger,Sarah Mayes,Madeleine E. Lemieux,Damien N. Barnette,Mala Gunadasa-Rohling,Ruth M. Williams,David R. Greaves,Le A. Trinh,Scott E. Fraser,Sarah L. Dallas,Robin P. Choudhury,Tatjana Sauka-Spengler,Paul R. Riley +22 more
TL;DR: An evolutionarily-conserved function of macrophages is identified that contributes directly to the forming post-injury scar through cell-autonomous deposition of collagen.
Journal ArticleDOI
VEGF Signaling through Neuropilin 1 Guides Commissural Axon Crossing at the Optic Chiasm
Lynda Erskine,Susan Reijntjes,Thomas Pratt,Laura Denti,Quenten Schwarz,Joaquim M. Vieira,Bennett Alakakone,Derryck Shewan,Christiana Ruhrberg +8 more
TL;DR: In vivo evidence is provided that VEGF-A is an essential axon guidance cue for axons at the chiasm midline and that NRP1 promotes contralateral RGC projection in mammals.