J
Joaquín Navascués
Researcher at University of Cantabria
Publications - 14
Citations - 1830
Joaquín Navascués is an academic researcher from University of Cantabria. The author has contributed to research in topics: Cajal body & Cell nucleus. The author has an hindex of 13, co-authored 14 publications receiving 1661 citations. Previous affiliations of Joaquín Navascués include University of Dundee.
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Journal ArticleDOI
The multifunctional nucleolus
TL;DR: Although the nucleolus is primarily associated with ribosome biogenesis, several lines of evidence now show that it has additional functions, such as regulation of mitosis, cell-cycle progression and proliferation, many forms of stress response and biogenesis of multiple ribonucleoprotein particles.
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Targeting of CTCF to the nucleolus inhibits nucleolar transcription through a poly(ADP-ribosyl)ation-dependent mechanism.
Verónica Torrano,Joaquín Navascués,Ru Zhang,Les J. Burke,Igor Chernukhin,Dawn Farrar,Javier León,Maria T. Berciano,Rainer Renkawitz,Elena Klenova,Miguel Lafarga,M. Dolores Delgado +11 more
TL;DR: The data show that nucleolar localization of CTCF is associated with growth arrest and it is demonstrated that the central zinc-finger domain of C TCF is the region responsible for nucleolar targeting.
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Oculopharyngeal muscular dystrophy-like nuclear inclusions are present in normal magnocellular neurosecretory neurons of the hypothalamus
Maria T. Berciano,Nuria T. Villagra,José L. Ojeda,Joaquín Navascués,Anita Quintal Gomes,Miguel Lafarga,Maria Carmo-Fonseca +6 more
TL;DR: The presence of intranuclear inclusions composed of tubular filaments in oxytocin-producing neurons from normal rat hypothalamus is reported, providing the first physiological evidence that polyalanine expansions are not essential to induce polymerization of PABPN1 into filamentous nuclear inclusions.
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Nuclear organization and dynamics of transcription sites in rat sensory ganglia neurons detected by incorporation of 5′-fluorouridine into nascent RNA
TL;DR: 5'-Fluorouridine incorporation in animal models provides a useful tool to investigate the organization of gene expression in mammalian neurons in both normal physiology and experimental pathology systems.
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Targeting SMN to Cajal bodies and nuclear gems during neuritogenesis
TL;DR: It is shown that the number and composition of the nuclear subdomains called Cajal bodies and gems changes during the course of N-ras-induced neuritogenesis in the PC12-derived cell line UR61, and that gems clearly represent a distinct category of nuclear body.