Jodene Eldstrom

TL;DR: Testing the hypothesis that there are further regional differences in the expression of Kv currents or the Kv subunits in mouse ventricular myocytes revealed no measurable differences in ECG parameters, including corrected QT (QTc) intervals, are detected in telemetric recordings from adult male and female mice.

TL;DR: Results suggest that in canine atria, as in other species including human, Kv1.5 protein is highly expressed and contributes to IKur.

TL;DR: The hypothesis that cholesterol modulates the turnover of voltage-gated potassium channels based on previous observations showing that depletion of membrane cholesterol increases the atrial repolarizing current IKur suggests that cholesterol regulates Kv1.5 channel expression by modulating its trafficking through the Rab11-associated recycling endosome.

TL;DR: EQQ and EQQQQ were found to have increasingly hyperpolarized activation, reduced conductance, and shorter first latency of opening compared to EQ - all abolished by the addition of KCNE1, demonstrating that no intrinsic mechanism limits the association of up to four β-subunits within the IKs complex.

TL;DR: A mechanism for KCNQ1 activation and inactivation is presented in which voltage sensor activation promotes pore opening more effectively in the intermediate open state than the fully open state, generating inactivation.