J
Joel D. Allen
Researcher at University of Southampton
Publications - 77
Citations - 4291
Joel D. Allen is an academic researcher from University of Southampton. The author has contributed to research in topics: Glycan & Glycosylation. The author has an hindex of 22, co-authored 63 publications receiving 2347 citations. Previous affiliations of Joel D. Allen include University of Oxford & Scripps Research Institute.
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Journal ArticleDOI
Site-specific glycan analysis of the SARS-CoV-2 spike.
Yasunori Watanabe,Yasunori Watanabe,Joel D. Allen,Daniel Wrapp,Jason S. McLellan,Max Crispin +5 more
TL;DR: It is shown how SARS-CoV-2 S glycans differ from typical host glycan processing, which may have implications in viral pathobiology and vaccine design, and enables mapping of the glycan-processing states across the trimeric viral spike.
Journal ArticleDOI
Quantitative mass imaging of single biological macromolecules
Gavin Young,Nikolas Hundt,Daniel Cole,Adam Fineberg,Joanna Andrecka,Andrew Tyler,Anna Olerinyova,A Ansari,Erik G. Marklund,Miranda P. Collier,Shane A. Chandler,Olga Tkachenko,Joel D. Allen,Max Crispin,Neil Billington,Yasuharu Takagi,James R. Sellers,Cédric Eichmann,Philipp Selenko,Lukas Frey,Roland Riek,Roland Riek,Martin R. Galpin,Weston B. Struwe,Justin L. P. Benesch,Philipp Kukura +25 more
TL;DR: Interferometric scattering mass spectrometry allows spatiotemporally resolved measurement of a broad range of biomolecular interactions, one molecule at a time, to characterize the molecular dynamics of processes as diverse as glycoprotein cross-linking, amyloidogenic protein aggregation, and actin polymerization.
Journal ArticleDOI
Vulnerabilities in coronavirus glycan shields despite extensive glycosylation.
Yasunori Watanabe,Zachary T. Berndsen,Jayna Raghwani,Gemma E. Seabright,Gemma E. Seabright,Joel D. Allen,Oliver G. Pybus,Jason S. McLellan,Ian A. Wilson,Thomas A. Bowden,Andrew B. Ward,Max Crispin +11 more
TL;DR: G glycans of coronavirus SARS and MERS S proteins are heterogeneously distributed and do not form an efficacious high-density global shield which would ensure efficient immune evasion, according to Watanabe et al.
Journal ArticleDOI
SARS-CoV-2 seroprevalence and asymptomatic viral carriage in healthcare workers: a cross-sectional study.
Adrian M Shields,Adrian M Shields,Sian E Faustini,Marisol Perez-Toledo,Sian E Jossi,Erin L. Aldera,Joel D. Allen,Saly Al-Taei,Claire Backhouse,Andrew Bosworth,Lyndsey A Dunbar,Daniel Ebanks,Beena Emmanuel,Mark I. Garvey,Mark I. Garvey,Joanna Gray,I. Michael Kidd,Golaleh McGinnell,Dee E McLoughlin,Gabriella L. Morley,Joanna O'Neill,Danai Papakonstantinou,Oliver J Pickles,Charlotte Poxon,Megan Richter,Eloise M Walker,Kasun Wanigasooriya,Yasunori Watanabe,Celina Whalley,Agnieszka E. Zielinska,Max Crispin,David C. Wraith,Andrew D Beggs,Adam F. Cunningham,Mark T. Drayson,Alex G. Richter,Alex G. Richter +36 more
TL;DR: Differences in the occupational risk of exposure to SARS-CoV-2 between hospital departments are identified and asymptomatic seroconversion occurs in healthcare workers to inform future infection control and occupational health practices.
Journal ArticleDOI
Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers
Talar Tokatlian,Benjamin J. Read,Christopher A. Jones,Daniel W. Kulp,Daniel W. Kulp,Daniel W. Kulp,Sergey Menis,Sergey Menis,Jason Y. Chang,Jon M. Steichen,Jon M. Steichen,Sudha Kumari,Joel D. Allen,Eric L. Dane,Alessia Liguori,Maya Sangesland,Daniel Lingwood,Max Crispin,William R. Schief,Darrell J. Irvine +19 more
TL;DR: These findings identify an innate immune–mediated recognition pathway promoting antibody responses to particulate antigens, with broad implications for humoral immunity and vaccine design.