J
Joel S. Pachter
Researcher at University of Connecticut Health Center
Publications - 78
Citations - 8476
Joel S. Pachter is an academic researcher from University of Connecticut Health Center. The author has contributed to research in topics: Blood–brain barrier & Chemokine. The author has an hindex of 37, co-authored 76 publications receiving 7730 citations. Previous affiliations of Joel S. Pachter include Johns Hopkins University School of Medicine & New York University.
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Journal ArticleDOI
Inflammation and Alzheimer's disease.
Haruhiko Akiyama,Steven W. Barger,Scott R. Barnum,B Bradt,Jürgen Bauer,Greg M. Cole,Neil R. Cooper,Piet Eikelenboom,Mark R. Emmerling,Bernd L. Fiebich,Caleb E. Finch,Sally A. Frautschy,W. S. T. Griffin,Harald Hampel,Michael Hüll,Gary E. Landreth,Lih-Fen Lue,Robert E. Mrak,Ian R. A. Mackenzie,Patrick L. McGeer,M K O'Banion,Joel S. Pachter,Giulio Maria Pasinetti,C Plata-Salaman,Joseph G. Rogers,Russell E. Rydel,Yueyang Shen,Wolfgang J. Streit,Ronald Strohmeyer,I Tooyoma,F L van Muiswinkel,R. Veerhuis,David G. Walker,Scott D. Webster,Beatrice Hauss–Wegrzyniak,Gary L. Wenk,Tony Wyss-Coray +36 more
TL;DR: By better understanding AD inflammatory and immunoregulatory processes, it should be possible to develop anti-inflammatory approaches that may not cure AD but will likely help slow the progression or delay the onset of this devastating disorder.
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The blood-brain barrier and its role in immune privilege in the central nervous system.
TL;DR: Those characteristics of the blood-brain barrier that play an important role in maintaining immune privilege in the CNS, as well as factors that regulate immune cell invasion through the BBB and thereby modulate immune responses in the nervous tissue are discussed.
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Autoregulation of tubulin expression is achieved through specific degradation of polysomal tubulin mRNAs
TL;DR: It is concluded that autoregulation of Tubulin synthesis is achieved by specifically altering the stability of tubulin RNAs that are bound to polyribosomes.
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The differential appearance of neurofilament triplet polypeptides in the developing rat optic nerve
Joel S. Pachter,Ronald K.H. Liem +1 more
TL;DR: The ontogenetic appearance of the individual triplet polypeptides that comprise mammalian neurofilaments was studied in the developing rat optic nerve and the potential physiological significance of the differential subunit transport is discussed with respect to neuronal differentiation in the developed mammalian CNS.
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Caveolin-1 regulates expression of junction-associated proteins in brain microvascular endothelial cells
TL;DR: Caveolin-1 loss is highlighted as a critical step in CCL2-induced modulation of BMEC junctional protein expression and integrity, and possibly serve a crucial role in regulating inflammation at the blood-brain barrier (BBB).