J
Johan Holmkvist
Researcher at Steno Diabetes Center
Publications - 25
Citations - 5320
Johan Holmkvist is an academic researcher from Steno Diabetes Center. The author has contributed to research in topics: Type 2 diabetes & Insulin resistance. The author has an hindex of 19, co-authored 25 publications receiving 5097 citations. Previous affiliations of Johan Holmkvist include Malmö University & University of Copenhagen.
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Journal ArticleDOI
Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels
Richa Saxena,Benjamin F. Voight,Valeriya Lyssenko,Noël P. Burtt,Paul I.W. de Bakker,Hong Chen,Jeffrey J. Roix,Sekar Kathiresan,Joel N. Hirschhorn,Mark J. Daly,Thomas E. Hughes,Leif Groop,David Altshuler,Peter Almgren,Jose C. Florez,Joanne M. Meyer,Kristin Ardlie,Kristina Bengtsson Boström,Bo Isomaa,Guillaume Lettre,Ulf Lindblad,Helen N. Lyon,Olle Melander,Christopher Newton-Cheh,Peter Nilsson,Marju Orho-Melander,Lennart Råstam,Elizabeth K. Speliotes,Marja-Riitta Taskinen,Tiinamaija Tuomi,Candace Guiducci,Anna Berglund,Joyce Carlson,Lauren Gianniny,Rachel Hackett,Liselotte Hall,Johan Holmkvist,Esa Laurila,Marketa Sjögren,Maria Sterner,Aarti Surti,Margareta Svensson,Malin Svensson,Ryan Tewhey,Brendan Blumenstiel,Melissa Parkin,Matthew DeFelice,Rachel Barry,Wendy Brodeur,Jody Camarata,Nancy Chia,Mary Fava,John G. Gibbons,Bob Handsaker,Claire M. Healy,Kieu Nguyen,Casey Gates,Carrie Sougnez,Diane Gage,Marcia M. Nizzari,Stacey Gabriel,Gung-Wei Chirn,Qicheng Ma,Hemang Parikh,Delwood Richardson,Darrell O. Ricke,Shaun Purcell +66 more
TL;DR: The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases.
Journal ArticleDOI
A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk
Nabila Bouatia-Naji,Amélie Bonnefond,Amélie Bonnefond,Christine Cavalcanti-Proença,Christine Cavalcanti-Proença,Thomas Sparsø,Johan Holmkvist,Marion Marchand,Marion Marchand,Jérôme Delplanque,Jérôme Delplanque,Stéphane Lobbens,Stéphane Lobbens,Ghislain Rocheleau,Emmanuelle Durand,Emmanuelle Durand,Franck De Graeve,Franck De Graeve,Jean-Claude Chèvre,Jean-Claude Chèvre,Knut Borch-Johnsen,Anna-Liisa Hartikainen,Aimo Ruokonen,Jean Tichet,Michel Marre,Michel Marre,Jacques Weill,Barbara Heude,Barbara Heude,Maithé Tauber,Katleen Lemaire,Frans Schuit,Paul Elliott,Torben Jørgensen,Guillaume Charpentier,Samy Hadjadj,Stéphane Cauchi,Stéphane Cauchi,Martine Vaxillaire,Martine Vaxillaire,Robert Sladek,Sophie Visvikis-Siest,Beverley Balkau,Beverley Balkau,Claire Levy-Marchal,Claire Levy-Marchal,François Pattou,David Meyre,David Meyre,Alexandra I. F. Blakemore,M. R. Järvelin,M. R. Järvelin,Andrew Walley,Torben Hansen,Christian Dina,Christian Dina,Oluf Pedersen,Oluf Pedersen,Philippe Froguel,Philippe Froguel,Philippe Froguel +60 more
TL;DR: The data suggest a possible link between circadian rhythm regulation and glucose homeostasis through the melatonin signaling pathway and show MT2 expression in human pancreatic islets and beta cells.
Journal ArticleDOI
Resequencing of 200 human exomes identifies an excess of low-frequency non-synonymous coding variants
Yingrui Li,Nicolas Vinckenbosch,Geng Tian,Emilia Huerta-Sanchez,Tao Jiang,Hui Jiang,Anders Albrechtsen,Gitte Andersen,Hongzhi Cao,Thorfinn Sand Korneliussen,Niels Grarup,Yiran Guo,Ines Hellman,Xin Jin,Qibin Li,Jiangtao Liu,Xiao Liu,Thomas Sparsø,Meifang Tang,Honglong Wu,Renhua Wu,Chang Yu,Hancheng Zheng,Arne Astrup,Lars Bolund,Lars Bolund,Johan Holmkvist,Torben Jørgensen,Torben Jørgensen,Karsten Kristiansen,Ole Schmitz,Ole Schmitz,Thue W. Schwartz,Xiuqing Zhang,Ruiqiang Li,Huanming Yang,Jing Wang,Torben Hansen,Oluf Pedersen,Oluf Pedersen,Rasmus Nielsen,Rasmus Nielsen,Jun Wang +42 more
TL;DR: Exome sequencing of 200 individuals from Denmark with targeted capture of 18,654 coding genes and sequence coverage of each individual exome at an average depth of 12-fold is reported, suggesting that deleterious substitutions are primarily recessive.
Journal ArticleDOI
Haplotype Structure and Genotype-Phenotype Correlations of the Sulfonylurea Receptor and the Islet ATP-Sensitive Potassium Channel Gene Region
Jose C. Florez,Noël P. Burtt,Paul I.W. de Bakker,Peter Almgren,Tiinamaija Tuomi,Johan Holmkvist,Daniel Gaudet,Thomas J. Hudson,Steve F. Schaffner,Mark J. Daly,Joel N. Hirschhorn,Leif Groop,David Altshuler +12 more
TL;DR: It is shown that E23K is also associated with decreased insulin secretion in glucose-tolerant control subjects, supporting a mechanism whereby beta-cell dysfunction contributes to the common form of type 2 diabetes.
Journal ArticleDOI
Genetic and epigenetic factors are associated with expression of respiratory chain component NDUFB6 in human skeletal muscle
Charlotte Ling,Pernille Poulsen,Stina Simonsson,Tina Rönn,Johan Holmkvist,Peter Almgren,Per Hagert,Emma Nilsson,Amanda G. Mabey,Peter M. Nilsson,Allan Vaag,Leif Groop +11 more
TL;DR: The results demonstrate that genetic, epigenetic, and nongenetic factors associate with NDUFB6 expression in human muscle and suggest that genetic and epigenetic factors may interact to increase age-dependent susceptibility to insulin resistance.