J
Johan Rönnelid
Researcher at Uppsala University
Publications - 223
Citations - 11659
Johan Rönnelid is an academic researcher from Uppsala University. The author has contributed to research in topics: Rheumatoid arthritis & Autoantibody. The author has an hindex of 48, co-authored 206 publications receiving 10361 citations. Previous affiliations of Johan Rönnelid include Uppsala University Hospital & Karolinska University Hospital.
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Journal ArticleDOI
A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination.
Lars Klareskog,Patrik Stolt,Karin Lundberg,Henrik Källberg,Camilla Bengtsson,Johan Grunewald,Johan Rönnelid,Helena Erlandsson Harris,Ann-Kristin Ulfgren,Solbritt Rantapää-Dahlqvist,Anders Eklund,Leonid Padyukov,Lars Alfredsson +12 more
TL;DR: An etiology involving a specific genotype, an environmental provocation, and the induction of specific autoimmunity are suggested, all restricted to a distinct subset of RA.
Journal ArticleDOI
International recommendations for the assessment of autoantibodies to cellular antigens referred to as anti-nuclear antibodies
Nancy Agmon-Levin,Nancy Agmon-Levin,Jan Damoiseaux,Cornelis Kallenberg,Ulrich Sack,Torsten Witte,Manfred Herold,Manfred Herold,Xavier Bossuyt,L. Musset,Ricard Cervera,Aresio Plaza-Lopez,Carlos Tadeu dos Santos Dias,Maria José Rego Sousa,Antonella Radice,Catharina Eriksson,Olof Hultgren,Markku Viander,Munther A. Khamashta,Stephan Regenass,Luis Eduardo Coelho Andrade,Allan Wiik,Angela Tincani,Johan Rönnelid,Daniel Bloch,Marvin J. Fritzler,Edward K. L. Chan,I. Garcia-De La Torre,Konstantin N. Konstantinov,Robert Lahita,Merlin R. Wilson,Olli Vainio,Nicole Fabien,Renato Alberto Sinico,Pier Luigi Meroni,Yehuda Shoenfeld,Yehuda Shoenfeld +36 more
TL;DR: Recommendations for the assessment and interpretation of ANA and associated antibodies were formulated and the roles of IIFA as a reference method, and the importance of defining nuclear and cytoplasmic staining were emphasised, while the need to incorporate alternative automated methods was acknowledged.
Journal ArticleDOI
Immunity to Citrullinated Proteins in Rheumatoid Arthritis
TL;DR: A new etiological model is proposed for ACPA-positive RA, built on MHC class II-dependent activation of adaptive immunity, which provides a new basis for molecular studies on the pathogenesis of AC PA-positive arthritis.
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Gene-Gene and Gene-Environment Interactions Involving HLA-DRB1, PTPN22, and Smoking in Two Subsets of Rheumatoid Arthritis
Henrik Källberg,Leonid Padyukov,Robert M. Plenge,Robert M. Plenge,Johan Rönnelid,Peter K. Gregersen,Annette H M van der Helm-van Mil,Annette H M van der Helm-van Mil,René E. M. Toes,René E. M. Toes,Tom W J Huizinga,Tom W J Huizinga,Lars Klareskog,Lars Alfredsson,Lars Alfredsson +14 more
TL;DR: A new pattern of interactions is described between the two major known genetic risk factors and the major environmental risk factor concerning the risk of developing anti-CCP-positive RA, extending the basis for a pathogenetic hypothesis for RA involving genetic and environmental factors.
Journal ArticleDOI
Activation of the type I interferon system in primary Sjogren's syndrome : a possible etiopathogenic mechanism
Ullvi Båve,Gunnel Nordmark,Tanja Lövgren,Johan Rönnelid,Stefan Cajander,Maija-Leena Eloranta,Gunnar V. Alm,Lars Rönnblom +7 more
TL;DR: Patients with primary SS have an activated type I IFN system that promotes the autoimmune process by a vicious circle-like mechanism, with increased autoantibody production and formation of more endogenous IFNalpha inducers.