J
Johan Vallon-Christersson
Researcher at Lund University
Publications - 99
Citations - 7444
Johan Vallon-Christersson is an academic researcher from Lund University. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 38, co-authored 80 publications receiving 5956 citations. Previous affiliations of Johan Vallon-Christersson include National Institutes of Health.
Papers
More filters
Journal ArticleDOI
Tertiary lymphoid structures improve immunotherapy and survival in melanoma.
Rita Cabrita,Martin Lauss,Adriana Sanna,Marco Donia,Mathilde Skaarup Larsen,Shamik Mitra,Iva Johansson,Bengt Phung,Katja Harbst,Johan Vallon-Christersson,Alison van Schoiack,Kristina Lövgren,Sarah Warren,Karin Jirström,Håkan Olsson,Kristian Pietras,Christian Ingvar,Karolin Isaksson,Dirk Schadendorf,Henrik Schmidt,Lars Bastholt,Ana Carneiro,Jennifer A. Wargo,Inge Marie Svane,Göran Jönsson +24 more
TL;DR: It is found that the co-occurrence of tumour-associated CD8 + T cells and CD20 + B cells, and the formation of tertiary lymphoid structures, are linked with improved survival in cohorts of patients with metastatic melanoma.
Journal ArticleDOI
Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype.
Linda Holmquist-Mengelbier,Erik Fredlund,Tobias Löfstedt,Rosa Noguera,Samuel Navarro,Helén Nilsson,Alexander Pietras,Johan Vallon-Christersson,Åke Borg,Katarina Gradin,Lorenz Poellinger,Sven Påhlman +11 more
TL;DR: High HIF-2alpha protein levels were correlated with advanced clinical stage and high VEGF expression and predicted poor prognosis in a clinical neuroblastoma material and have general tumor biological implications.
Journal ArticleDOI
BioArray Software Environment (BASE): a platform for comprehensive management and analysis of microarray data
Lao H. Saal,Lao H. Saal,Carl Troein,Johan Vallon-Christersson,Sofia Gruvberger,Åke Borg,Carsten Peterson +6 more
TL;DR: This work presents a web-based customizable bioinformatics solution called BioArray Software Environment (BASE) for the management and analysis of all areas of microarray experimentation.
Journal ArticleDOI
Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair
Lao H. Saal,Sofia K. Gruvberger-Saal,Camilla Persson,Kristina Lövgren,Mervi Jumppanen,Johan Staaf,Göran Jönsson,Maira M. Pires,Matthew Maurer,Karolina Holm,Susan Koujak,Shivakumar Subramaniyam,Johan Vallon-Christersson,Håkan Olsson,Tao Su,Lorenzo Memeo,Thomas Ludwig,Stephen P. Ethier,Morten Krogh,Matthias Szabolcs,Vundavalli V. Murty,Jorma Isola,Hanina Hibshoosh,Ramon Parsons,Åke Borg +24 more
TL;DR: It is shown that heterozygous inactivation of the tumor suppressor gene Pten leads to the formation of basal-like mammary tumors in mice, and that loss of PTEN expression is significantly associated with the BBC subtype in human sporadic and BRCA1-associated hereditary breast cancers.
Journal ArticleDOI
Molecular subtypes of breast cancer are associated with characteristic DNA methylation patterns
Karolina Holm,Cecilia Hegardt,Johan Staaf,Johan Vallon-Christersson,Göran Jönsson,Håkan Olsson,Åke Borg,Markus Ringnér +7 more
TL;DR: It is found that breast cancers of the basal-like, luminal A and luminal B molecular subtypes harbour specific methylation profiles, suggesting that methylation may play an important role in the development of breast cancers.