J
Johan Wouter Jukema
Researcher at Leiden University Medical Center
Publications - 105
Citations - 4890
Johan Wouter Jukema is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Coronary artery disease & Cardiac imaging. The author has an hindex of 30, co-authored 105 publications receiving 4432 citations. Previous affiliations of Johan Wouter Jukema include Leiden University.
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Journal ArticleDOI
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis.
Daniel I. Swerdlow,Michael V. Holmes,Karoline Kuchenbaecker,Engmann Jel.,Tina Shah,Reecha Sofat,Yiran Guo,C Chung,Anne Peasey,Roman Pfister,Simon P. Mooijaart,Helen Ireland,Maarten Leusink,Claudia Langenberg,KaWah Li,Jutta Palmen,Phil Howard,Jackie A. Cooper,Fotios Drenos,John Hardy,Mike A. Nalls,Yun Li,Gordon D.O. Lowe,Marlene C. W. Stewart,S. J. Bielinski,Julian Peto,Nicholas J. Timpson,John Gallacher,Malcolm G. Dunlop,Richard S. Houlston,Ian Tomlinson,Ioanna Tzoulaki,Jian'an Luan,Boer Jma.,Nita G. Forouhi,N. C. Onland-Moret,Y. T. van der Schouw,Renate B. Schnabel,Jaroslav A. Hubacek,Růžena Kubínová,Migle Baceviciene,Abdonas Tamosiunas,Andrzej Pajak,Roman Topor-Madry,Sofia Malyutina,Damiano Baldassarre,Bengt Sennblad,Elena Tremoli,U de Faire,Luigi Ferrucci,S Bandenelli,Tetsu Tanaka,James F. Meschia,AB Singleton,Gerjan Navis,I. Mateo Leach,Bakker Sjl.,Ron T. Gansevoort,Ian Ford,Stephen E. Epstein,Mary-Susan Burnett,Joe Devaney,Johan Wouter Jukema,Westendorp Rgj.,G Jan de Borst,Y. van der Graaf,P A de Jong,Mailand-van der Zee A-H.,Olaf H. Klungel,A. de Boer,P. A. Doevendans,Jeffrey W. Stephens,Charles B. Eaton,Jennifer G. Robinson,JoAnn E. Manson,F G Fowkes,Timothy M. Frayling,Jenna Price,Peter H. Whincup,Richard W Morris,Debbie A Lawlor,George Davey Smith,Yoav Ben-Shlomo,Susan Redline,Leslie A. Lange,Meena Kumari,Nicholas J. Wareham,Verschuren Wmm.,Emelia J. Benjamin,John C. Whittaker,Anders Hamsten,Frank Dudbridge,Delaney Jac.,Andrew Wong,Diana Kuh,Rebecca Hardy,Berta Almoguera Castillo,John Connolly,P. van der Harst,Eric J. Brunner,Michael Marmot,Christina L. Wassel,Steve E. Humphries,P.J. Talmud,Mika Kivimäki,Folkert W. Asselbergs,Mikhail I. Voevoda,Martin Bobak,Hynek Pikhart,James G. Wilson,Hakon Hakonarson,Alexander P. Reiner,Brendan J. Keating,Naveed Sattar,Aroon D. Hingorani,Juan P. Casas +115 more
TL;DR: IL6R blockade could provide a novel therapeutic approach to prevention of coronary heart disease that warrants testing in suitably powered randomised trials and could help to validate and prioritise novel drug targets or to repurpose existing agents and targets for new therapeutic uses.
Journal ArticleDOI
The role of a common variant of the cholesteryl ester transfer protein gene in the progression of coronary atherosclerosis. The Regression Growth Evaluation Statin Study Group
J. A. Kuivenhoven,Johan Wouter Jukema,Aeilko H. Zwinderman,P. de Knijff,Ruth McPherson,A. V. G. Bruschke,Kong I. Lie,John J. P. Kastelein +7 more
TL;DR: This common DNA variant appears to predict whether men with coronary artery disease will benefit from treatment with pravastatin to delay the progression of coronary atherosclerosis, independent of plasma HDL cholesterol levels and the activities of lipolytic plasma enzymes.
Journal ArticleDOI
Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949)
Gary Davies,Nicola J. Armstrong,J. C. Bis,Jan Bressler,Vincent Chouraki,Vincent Chouraki,Sudheer Giddaluru,Edith Hofer,Carla A. Ibrahim-Verbaas,Mirna Kirin,Jari Lahti,S. J. van der Lee,S. Le Hellard,Tian Liu,Riccardo E. Marioni,Riccardo E. Marioni,Christopher Oldmeadow,Iris Postmus,Albert V. Smith,Jennifer A. Smith,Anbupalam Thalamuthu,Russell Thomson,Veronique Vitart,Jing Wang,Jing Wang,Le Yu,Lina Zgaga,Lina Zgaga,Wei Zhao,Ruth Boxall,Sarah E. Harris,WD Hill,D C Liewald,Michelle Luciano,Hieab H.H. Adams,David Ames,David Ames,Najaf Amin,P. Amouyel,Amelia A. Assareh,Rhoda Au,Rhoda Au,James T. Becker,Alexa S. Beiser,Alexa S. Beiser,Claudine Berr,Claudine Berr,Lars Bertram,Lars Bertram,Eric Boerwinkle,Eric Boerwinkle,Brendan M. Buckley,Harry Campbell,Janie Corley,P. L. De Jager,P. L. De Jager,Carole Dufouil,Johan G. Eriksson,Johan G. Eriksson,Thomas Espeseth,Jessica D. Faul,Ian Ford,Generation Scotland,Rebecca F. Gottesman,Michael Griswold,Vilmundur Gudnason,T.B. Harris,Gerardo Heiss,Albert Hofman,Elizabeth G. Holliday,Jennifer E. Huffman,Sharon L.R. Kardia,Nicole A. Kochan,D. S. Knopman,John B.J. Kwok,John B.J. Kwok,Jean-Charles Lambert,Teresa Lee,Ge Li,Shu-Chen Li,Shu-Chen Li,Marisa Loitfelder,Oscar L. Lopez,Astri J. Lundervold,Astri J. Lundervold,A. Lundqvist,Karen A. Mather,Saira Saeed Mirza,Lars Nyberg,Ben A. Oostra,Aarno Palotie,Aarno Palotie,Goran Papenberg,Goran Papenberg,Alison Pattie,Katja Petrovic,Ozren Polasek,Bruce M. Psaty,Bruce M. Psaty,Paul Redmond,Simone Reppermund,Jerome I. Rotter,Helena Schmidt,Maaike Schuur,Peter W. Schofield,Rodney J. Scott,Vidar M. Steen,David J. Stott,J. C. van Swieten,K. D. Taylor,Julian N. Trollor,Stella Trompet,André G. Uitterlinden,Galit Weinstein,Galit Weinstein,Elisabeth Widen,Beverly G Windham,Johan Wouter Jukema,Alan F. Wright,Margaret J. Wright,Qiong Yang,Qiong Yang,Hélène Amieva,John Attia,David A. Bennett,Henry Brodaty,A.J.M. de Craen,Caroline Hayward,M. A. Ikram,Ulman Lindenberger,Lars-Göran Nilsson,David J. Porteous,Katri Räikkönen,Ivar Reinvang,Igor Rudan,Perminder S. Sachdev,Reinhold Schmidt,Peter R. Schofield,Peter R. Schofield,Velandai Srikanth,Velandai Srikanth,John M. Starr,Stephen T. Turner,David R. Weir,James F. Wilson,C M van Duijn,L. J. Launer,Annette L. Fitzpatrick,Sudha Seshadri,Sudha Seshadri,Thomas H. Mosley,Ian J. Deary +151 more
TL;DR: In hypothesis-driven tests, there was significant association between general cognitive function and four genes previously associated with Alzheimer’s disease: TOMM40, APOE, ABCG1 and MEF2C.
Journal ArticleDOI
Thermolabile Methylenetetrahydrofolate Reductase in Coronary Artery Disease
Leo A. J. Kluijtmans,J.J.P. Kastelein,Jan Lindemans,Godfried H.J. Boers,Sandra G. Heil,A. V. G. Bruschke,Johan Wouter Jukema,L.P.W.J. van den Heuvel,F.J.M. Trijbels,G.J.M. Boerma,Freek W.A. Verheugt,F.F. Willems,Henk J. Blom +12 more
TL;DR: In this article, a 677C→T mutation in the MTHFR gene has been associated with elevated homocysteine concentrations in homozygous (+/+) individuals, resulting in an odds ratio of 1.21 (95% confidence interval [CI], 0.87 to 1.68), relative to the (−/−) genotype.
Journal ArticleDOI
Differential effect of the rs4149056 variant in SLCO1B1 on myopathy associated with simvastatin and atorvastatin
Liam R. Brunham,P. J. Lansberg,Lin-Hua Zhang,Fudan Miao,Cedric J. Carter,G.K. Hovingh,Henk Visscher,Johan Wouter Jukema,Anton F. H. Stalenhoef,Colin J. D. Ross,Bruce Carleton,John J. P. Kastelein,Michael R. Hayden +12 more
TL;DR: The findings provide further support for a role for SLCO1B1 genotype in simvastatin-associated myopathy, and suggest that this association may be stronger for simvastsatin compared with atorvastasin.