J
Johannes B. Prins
Researcher at University of Queensland
Publications - 174
Citations - 15336
Johannes B. Prins is an academic researcher from University of Queensland. The author has contributed to research in topics: Adipose tissue & Insulin resistance. The author has an hindex of 55, co-authored 168 publications receiving 14638 citations. Previous affiliations of Johannes B. Prins include Mater Health Services & University of Cambridge.
Papers
More filters
Journal ArticleDOI
Congenital leptin deficiency is associated with severe early-onset obesity in humans
C. T. Montague,I S Farooqi,Jonathan P. Whitehead,Maria A. Soos,Harald Rau,Nicholas J. Wareham,C. P. Sewter,JE Digby,S N Mohammed,J A Hurst,C H Cheetham,A R Earley,Anthony H. Barnett,Johannes B. Prins,Stephen O'Rahilly +14 more
TL;DR: The severe obesity found in two severely obese children who are members of the same highly consanguineous pedigree provides the first genetic evidence that leptin is an important regulator of energy balance in humans.
Journal ArticleDOI
Diabetic Cardiomyopathy: Evidence, Mechanisms, and Therapeutic Implications
TL;DR: Evidence is presented that diabetes is associated with a cardiomyopathy, independent of comorbid conditions, and that metabolic disturbances, myocardial fibrosis, small vessel disease, cardiac autonomic neuropathy, and insulin resistance may all contribute to the development of diabetic heart disease.
Journal ArticleDOI
The prevalence and impact of overweight and obesity in an Australian obstetric population.
TL;DR: Assessment of the prevalence and impact of overweight and obesity in an Australian obstetric population finds that women are more likely to be overweight or obese than the general population.
Journal ArticleDOI
Adiponectin--a key adipokine in the metabolic syndrome.
Jonathan P. Whitehead,Ayanthi A. Richards,Ingrid J. Hickman,Graeme A. Macdonald,Johannes B. Prins +4 more
TL;DR: Given the low levels of adiponectin in subjects with the metabolic syndrome, and the beneficial effect of the adipokine in animal studies, there is exciting potential for adiponECTin replacement therapy in insulin resistance and related disorders.
Journal ArticleDOI
Depot- and Sex-Specific Differences in Human Leptin mRNA Expression: Implications for the Control of Regional Fat Distribution
TL;DR: Leptin mRNA appears to be expressed predominantly by subcutaneous adipocytes, particularly in women, suggesting a possible role for leptin in the control of adipose tissue distribution and mass.