J
Johannes C. Melms
Researcher at Columbia University
Publications - 36
Citations - 2144
Johannes C. Melms is an academic researcher from Columbia University. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 10, co-authored 17 publications receiving 832 citations. Previous affiliations of Johannes C. Melms include Broad Institute & Columbia University Medical Center.
Papers
More filters
Journal ArticleDOI
A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade
Livnat Jerby-Arnon,Parin Shah,Michael S. Cuoco,Christopher Rodman,Mei-Ju Su,Johannes C. Melms,Rachel Leeson,Abhay Kanodia,Shaolin Mei,Jia-Ren Lin,Shu Wang,Bokang Rabasha,David Liu,Gao Zhang,Claire Margolais,Orr Ashenberg,Patrick A. Ott,Elizabeth I. Buchbinder,Rizwan Haq,F. Stephen Hodi,Genevieve M. Boland,Ryan J. Sullivan,Dennie T. Frederick,Benchun Miao,Tabea Moll,Keith T. Flaherty,Meenhard Herlyn,Russell W. Jenkins,Rohit Thummalapalli,Monika S. Kowalczyk,Israel Cañadas,Bastian Schilling,Bastian Schilling,Adam N.R. Cartwright,Adrienne M. Luoma,Shruti Malu,Patrick Hwu,Chantale Bernatchez,Marie Andrée Forget,David A. Barbie,Alex K. Shalek,Itay Tirosh,Peter K. Sorger,Kai W. Wucherpfennig,Eliezer M. Van Allen,Dirk Schadendorf,Bruce E. Johnson,Asaf Rotem,Asaf Rotem,Orit Rozenblatt-Rosen,Levi A. Garraway,Charles H. Yoon,Charles H. Yoon,Benjamin Izar,Aviv Regev +54 more
TL;DR: A resistance program expressed by malignant cells that is associated with T cell exclusion and immune evasion is identified, and this study provides a high-resolution landscape of ICI-resistant cell states, identifies clinically predictive signatures, and suggests new therapeutic strategies to overcome immunotherapy resistance.
Journal ArticleDOI
COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets.
Toni Delorey,Carly G. K. Ziegler,Graham Heimberg,Rachelly Normand,Yiming Yang,Yiming Yang,Asa Segerstolpe,Domenic Abbondanza,Stephen J. Fleming,Ayshwarya Subramanian,Daniel T. Montoro,Karthik A. Jagadeesh,Kushal K. Dey,Pritha Sen,Michal Slyper,Yered Pita-Juárez,Devan Phillips,Jana Biermann,Zohar Bloom-Ackermann,Nikolaos Barkas,Andrea Ganna,Andrea Ganna,James Gomez,Johannes C. Melms,Igor Katsyv,Erica Normandin,Erica Normandin,Pourya Naderi,Pourya Naderi,Yury Popov,Yury Popov,Siddharth S. Raju,Siddharth S. Raju,Sebastian Niezen,Sebastian Niezen,Linus T.-Y. Tsai,Katherine J. Siddle,Katherine J. Siddle,Malika Sud,Victoria M. Tran,Shamsudheen K. Vellarikkal,Shamsudheen K. Vellarikkal,Yiping Wang,Liat Amir-Zilberstein,Deepak Atri,Deepak Atri,Joseph M. Beechem,Olga R. Brook,Jonathan H. Chen,Jonathan H. Chen,Prajan Divakar,Phylicia Dorceus,Jesse M. Engreitz,Jesse M. Engreitz,Adam Essene,Donna M. Fitzgerald,Robin Fropf,Steven Gazal,Joshua Gould,John Grzyb,Tyler Harvey,Jonathan L. Hecht,Jonathan L. Hecht,Tyler Hether,Judit Jané-Valbuena,Michael Leney-Greene,Hui Ma,Hui Ma,Cristin McCabe,Daniel E. McLoughlin,Eric M. Miller,Christoph Muus,Christoph Muus,Mari Niemi,Robert F. Padera,Robert F. Padera,Robert F. Padera,Liuliu Pan,Deepti Pant,Carmel Pe’er,Jenna Pfiffner-Borges,Christopher J. Pinto,Jacob Plaisted,Jason Reeves,Marty Ross,Melissa Rudy,Erroll H. Rueckert,Michelle Siciliano,Alexander Sturm,Ellen Todres,Avinash Waghray,Sarah Warren,Shuting Zhang,Daniel R. Zollinger,Lisa A. Cosimi,Rajat M. Gupta,Rajat M. Gupta,Nir Hacohen,Nir Hacohen,Hanina Hibshoosh,Winston Hide,Alkes L. Price,Jayaraj Rajagopal,Purushothama Rao Tata,Stefan Riedel,Stefan Riedel,Gyongyi Szabo,Gyongyi Szabo,Gyongyi Szabo,Timothy L. Tickle,Patrick T. Ellinor,Deborah T. Hung,Deborah T. Hung,Pardis C. Sabeti,Richard M. Novak,Robert S. Rogers,Robert S. Rogers,Donald E. Ingber,Donald E. Ingber,Donald E. Ingber,Z. Gordon Jiang,Z. Gordon Jiang,Dejan Juric,Mehrtash Babadi,Samouil L. Farhi,Benjamin Izar,James R. Stone,Ioannis S. Vlachos,Isaac H. Solomon,Orr Ashenberg,Caroline B. M. Porter,Bo Li,Bo Li,Alex K. Shalek,Alexandra-Chloé Villani,Orit Rozenblatt-Rosen,Orit Rozenblatt-Rosen,Aviv Regev +137 more
TL;DR: In this article, single-cell analysis of lung, heart, kidney and liver autopsy samples shows the molecular and cellular changes and immune response resulting from severe SARS-CoV-2 infection.
Journal ArticleDOI
A molecular single-cell lung atlas of lethal COVID-19.
Johannes C. Melms,Jana Biermann,Huachao Huang,Yiping Wang,Ajay Nair,Somnath Tagore,Igor Katsyv,André F. Rendeiro,Amit Dipak Amin,Denis Schapiro,Denis Schapiro,Chris J. Frangieh,Chris J. Frangieh,Adrienne M. Luoma,Aveline Filliol,Yinshan Fang,Hiranmayi Ravichandran,Mariano G. Clausi,George A. Alba,Meri Rogava,Sean W. Chen,Patricia Ho,Daniel T. Montoro,Daniel T. Montoro,Adam E. Kornberg,Arnold Han,Mathieu F. Bakhoum,Niroshana Anandasabapathy,Mayte Suárez-Fariñas,Samuel F. Bakhoum,Yaron Bram,Alain C. Borczuk,Xinzheng V. Guo,Jay H. Lefkowitch,Charles C. Marboe,Stephen M. Lagana,Armando Del Portillo,Emily J. Tsai,Emmanuel Zorn,Glen S. Markowitz,Robert F. Schwabe,Robert E. Schwartz,Olivier Elemento,Anjali Saqi,Hanina Hibshoosh,Jianwen Que,Benjamin Izar +46 more
TL;DR: In this paper, the authors performed single-nucleus RNA sequencing of about 116,000 nuclei from the lungs of nineteen individuals who died of COVID-19 and underwent rapid autopsy and seven control individuals.
Journal ArticleDOI
A single-cell landscape of high-grade serous ovarian cancer.
Benjamin Izar,Itay Tirosh,Elizabeth H. Stover,Isaac Wakiro,Michael S. Cuoco,Idan Alter,Christopher Rodman,Rachel Leeson,Mei-Ju Su,Parin Shah,Marcin P. Iwanicki,Sarah R. Walker,Abhay Kanodia,Johannes C. Melms,Shaolin Mei,Jia-Ren Lin,Caroline B. M. Porter,Michal Slyper,Julia Waldman,Livnat Jerby-Arnon,Orr Ashenberg,Titus J. Brinker,Caitlin E. Mills,Meri Rogava,Sébastien Vigneau,Peter K. Sorger,Levi A. Garraway,Panagiotis A. Konstantinopoulos,Joyce F. Liu,Ursula A. Matulonis,Bruce E. Johnson,Orit Rozenblatt-Rosen,Asaf Rotem,Asaf Rotem,Aviv Regev +34 more
TL;DR: Significant inter-patient variability is found in the composition and functional programs of ascites cells, including immunomodulatory fibroblast sub-populations and dichotomous macrophage populations, which contributes to resolving the HSGOC landscape and provides a resource for the development of novel therapeutic approaches.
Journal ArticleDOI
Metastasis and Immune Evasion from Extracellular cGAMP Hydrolysis.
Jun Li,Mercedes Duran,Ninjit Dhanota,Walid K. Chatila,Walid K. Chatila,Sarah E Bettigole,John Kwon,Roshan K. Sriram,Matthew P. Humphries,Manuel Salto-Tellez,Manuel Salto-Tellez,Jacqueline James,Matthew G. Hanna,Johannes C. Melms,Sreeram Vallabhaneni,Kevin Litchfield,Ieva Usaite,Dhruva Biswas,Rohan Bareja,Hao Wei Li,Maria Laura Martin,Princesca Dorsaint,Julie-Ann Cavallo,Peng Li,Chantal Pauli,Lee S. Gottesdiener,Benjamin J DiPardo,Travis J Hollmann,Taha Merghoub,Hannah Y Wen,Jorge S. Reis-Filho,Nadeem Riaz,Shin-San Michael Su,Anusha Kalbasi,Neil Vasan,Neil Vasan,Simon N. Powell,Jedd D. Wolchok,Olivier Elemento,Charles Swanton,Alexander N. Shoushtari,Alexander N. Shoushtari,Eileen Parkes,Eileen Parkes,Benjamin Izar,Samuel F. Bakhoum +45 more
TL;DR: In this article, the ectonucleotidase ENPP1 promotes metastasis by selectively degrading extracellular cGAMP, an immune-stimulatory metabolite whose breakdown products include the immune suppressor adenosine.