J
Johannes Doehmer
Researcher at Technische Universität München
Publications - 92
Citations - 3044
Johannes Doehmer is an academic researcher from Technische Universität München. The author has contributed to research in topics: Chinese hamster & Cell culture. The author has an hindex of 31, co-authored 92 publications receiving 2973 citations. Previous affiliations of Johannes Doehmer include University of Mainz.
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Journal ArticleDOI
Cytochrome P450 CYP1B1 determines susceptibility to 7,12-dimethylbenz[a]anthracene-induced lymphomas
Jeroen Buters,Shuichi Sakai,Thomas Richter,Thierry Pineau,David L. Alexander,Uzen Savas,Johannes Doehmer,Jerrold M. Ward,Colin R. Jefcoate,Frank J. Gonzalez +9 more
TL;DR: CYP1B1-null mice, created by targeted gene disruption in embryonic stem cells, were born at the expected frequency from heterozygous matings with no observable phenotype as discussed by the authors.
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Inhibition of cytochromes P4501A by nitric oxide
TL;DR: The results indicate that inhibition of NO biosynthesis in patients suffering from systemic inflammatory response syndromes may help to restore biotransformation capacity of the liver.
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Cytochrome P450 CYP1B1 protein expression: a novel mechanism of anticancer drug resistance.
Morag C.E. McFadyen,Howard L. McLeod,F. C. Jackson,William T. Melvin,Johannes Doehmer,Graeme I. Murray +5 more
TL;DR: This study is the first to indicate that the presence of CYP1B1 in cells decreases their sensitivity to the cytotoxic effects of a specific anticancer drug.
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Stable expression of rat cytochrome P-450IIB1 cDNA in Chinese hamster cells (V79) and metabolic activation of aflatoxin B1.
Johannes Doehmer,S. Dogra,Thomas Friedberg,Solange Monier,Milton Adesnik,Hansruedi Glatt,Franz Oesch +6 more
TL;DR: A full-length cDNA clone encoding the monooxygenase cytochrome P-450IIB1 under control of the simian virus 40 early promoter was constructed and cointroduced with the selection marker neomycin phosphotransferase into V79 Chinese hamster cells, and the gene product exhibited this activity.
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Biotransformation of caffeine and theophylline in mammalian cell lines genetically engineered for expression of single cytochrome P450 isoforms
TL;DR: The hypothesis that caffeine plasma clearance is a specific in vivo probe for determining human P450IA2 activity is supported.