J
John A.H. Lord
Researcher at University of Aberdeen
Publications - 8
Citations - 3408
John A.H. Lord is an academic researcher from University of Aberdeen. The author has contributed to research in topics: μ-opioid receptor & Receptor. The author has an hindex of 7, co-authored 8 publications receiving 3385 citations.
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Endogenous opioid peptides: multiple agonists and receptors
TL;DR: It is concluded that the opioid peptidergic system has agonists of different characteristics which interact with more than one type of receptor.
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Analogues of β-LPH61–64 posessing selective agonist activity at μ-opiate receptors
TL;DR: One of the compounds, RX783006 (HTyr-D-Ala-Gly-MePhe-NH(CH2)2OH), has been tritiated to high specific radioactivity and may prove to be a useful probe in the elucidation of the function of the heterogenous opiate receptor population.
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Effects of changes in the structure of enkephalins and of narcotic analgesic drugs on their interactions with μ and δ-receptors
TL;DR: In the alkaloid‐like series of narcotic analgesic drugs, ketobemidone, levorphanol, methadone, etorphine and the antagonist Mr 2266 had lower Nal/Leu ratios than morphine, normorphine, naloxone and naltrexone while compounds with high ratios interact mainly with μ‐receptors.
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Opioid activities of fragments of β-endorphin and of ites leucine65-analogue. Comparison of the binding properties of methionine- and leucine-enkephalin
TL;DR: No evidence was obtained for more than one type of delta-binding site in the guinea-pig ileum and mouse vas deferens as pharmacological models and the inhibition of binding of [3H]-naltrexone, [ 3H]-leucine-enkephalin and [3 H]-methione-encephalin was inhibited by cold ligands interacting with delta-, mu-, or kappa-receptors.
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Common anionic receptor site hypothesis: its relevance to the antagonist action of naloxone
TL;DR: Four alkoxy analogues of naloxone and naltrexone were generated in contradiction to the predictions of the common anionic receptor site hypothesis and did not significantly alter oral/parenteral ratios of durations of action.