J
John B. Davis
Researcher at University of Oxford
Publications - 141
Citations - 20383
John B. Davis is an academic researcher from University of Oxford. The author has contributed to research in topics: TRPV1 & Capsaicin. The author has an hindex of 65, co-authored 138 publications receiving 19415 citations. Previous affiliations of John B. Davis include University of Cambridge & Heidelberg University.
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Journal ArticleDOI
Hydrogen peroxide mediates amyloid beta protein toxicity.
TL;DR: The cytotoxic action of A beta on neurons results from free radical damage to susceptible cells, suggesting that A beta activates a member of this class of enzymes.
Journal ArticleDOI
Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia
John B. Davis,Julie E. Gray,Martin J. Gunthorpe,Jonathan P. Hatcher,Phil T. Davey,Philip Overend,Mark H Harries,Judi Latcham,Colin M. Clapham,Kirsty Atkinson,Stephen A. Hughes,Kim Rance,Evelyn Grau,Alex J. Harper,Perdita L. Pugh,Derek C. Rogers,Sharon Bingham,Andrew D. Randall,Steven A. Sheardown +18 more
TL;DR: It is concluded that VR1 is required for inflammatory sensitization to noxious thermal stimuli but also that alternative mechanisms are sufficient for normal sensation of noxious heat.
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Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide.
Tiziana Bisogno,Lumir Hanus,Luciano De Petrocellis,Susanna Tchilibon,Datta E. Ponde,Ines Brandi,Aniello Schiano Moriello,John B. Davis,Raphael Mechoulam,Vincenzo Di Marzo +9 more
TL;DR: Results suggest that VR1 receptors, or increased levels of endogenous AEA, might mediate some of the pharmacological effects of CBD and its analogues, and (−)‐5′‐DMH‐CBD represents a valuable candidate for further investigation as inhibitor of AEA uptake and a possible new therapeutic agent.
Journal ArticleDOI
Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system.
Mark A. Marchionni,Andrew Goodearl,Maio Su Chen,Olivia Bermingham-McDonogh,Cassandra Kirk,Marvin Hendricks,Frank Danehy,Don Misumi,Judith Sudhalter,Kazumi Kobayashi,Diana Wroblewski,Catherine Lynch,Mark Baldassare,Ian Hiles,John B. Davis,John B. Davis,J. Justin Hsuan,Nicholas F. Totty,Masayuki Otsu,Robert N. McBurney,Michael D. Waterfield,Paul Stroobant,David I. Gwynne +22 more
TL;DR: Alternative splicing of the messenger RNA generates an array of putative membrane-attached, intracellular and secreted signalling proteins, at least some of which are expressed in the developing spinal cord and brain.
Journal ArticleDOI
TRPV3 is a temperature-sensitive vanilloid receptor-like protein.
Graham D Smith,Martin J. Gunthorpe,Rosemary E. Kelsell,Philip David Hayes,P. Reilly,Paul Facer,James Wright,Jeffrey C. Jerman,Jean-Philippe Walhin,Lezanne Ooi,Julie Egerton,K. J. Charles,Darren Smart,Andrew D. Randall,Praveen Anand,John B. Davis +15 more
TL;DR: A member of the vanilloid receptor/TRP gene family, vanilloids receptor-like protein 3 (VRL3, also known as TRPV3), is identified, which is heat-sensitive but capsaicin-insensitive, suggesting the existence of thermosensitive receptors distinct from VR1.