抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Surface plasmons are waves that propagate along the surface of a conductor. By altering the structure of a metal's surface, the properties of surface plasmons--in particular their interaction with light--can be tailored, which offers the potential for developing new types of photonic device. This could lead to miniaturized photonic circuits with length scales that are much smaller than those currently achieved. Surface plasmons are being explored for their potential in subwavelength optics, data storage, light generation, microscopy and bio-photonics.

/pdf/surface-plasmon-subwavelength-optics-5e55p12p4o.pdf

Surface plasmon subwavelength optics

We present experimental scattering data at microwave frequencies on a structured metamaterial that exhibits a frequency band where the effective index of refraction (n) is negative. The material consists of a two-dimensional array of repeated unit cells of copper strips and split ring resonators on interlocking strips of standard circuit board material. By measuring the scattering angle of the transmitted beam through a prism fabricated from this material, we determine the effective n, appropriate to Snell's law. These experiments directly confirm the predictions of Maxwell's equations that n is given by the negative square root of epsilon.mu for the frequencies where both the permittivity (epsilon) and the permeability (mu) are negative. Configurations of geometrical optical designs are now possible that could not be realized by positive index materials.

/pdf/experimental-verification-of-a-negative-index-of-refraction-37hlxn3tta.pdf

Experimental Verification of a Negative Index of Refraction

We show that microstructures built from nonmagnetic conducting sheets exhibit an effective magnetic permeability /spl mu//sub eff/, which can be tuned to values not accessible in naturally occurring materials, including large imaginary components of /spl mu//sub eff/. The microstructure is on a scale much less than the wavelength of radiation, is not resolved by incident microwaves, and uses a very low density of metal so that structures can be extremely lightweight. Most of the structures are resonant due to internal capacitance and inductance, and resonant enhancement combined with compression of electrical energy into a very small volume greatly enhances the energy density at critical locations in the structure, easily by factors of a million and possibly by much more. Weakly nonlinear materials placed at these critical locations will show greatly enhanced effects raising the possibility of manufacturing active structures whose properties can be switched at will between many states.

/pdf/magnetism-from-conductors-and-enhanced-nonlinear-phenomena-2fpnoamwae.pdf

Magnetism from conductors and enhanced nonlinear phenomena

The emerging field of plasmonics has yielded methods for guiding and localizing light at the nanoscale, well below the scale of the wavelength of light in free space. Now plasmonics researchers are turning their attention to photovoltaics, where design approaches based on plasmonics can be used to improve absorption in photovoltaic devices, permitting a considerable reduction in the physical thickness of solar photovoltaic absorber layers, and yielding new options for solar-cell design. In this review, we survey recent advances at the intersection of plasmonics and photovoltaics and offer an outlook on the future of solar cells based on these principles.

Plasmonics for improved photovoltaic devices

Optical lenses have for centuries been one of scientists’ prime tools. Their operation is well understood on the basis of classical optics: curved surfaces focus light by virtue of the refractive index contrast. Equally their limitations are dictated by wave optics: no lens can focus light onto an area smaller than a square wavelength. What is there new to say other than to polish the lens more perfectly and to invent slightly better dielectrics? In this Letter I want to challenge the traditional limitation on lens performance and propose a class of “superlenses,” and to suggest a practical scheme for implementing such a lens. Let us look more closely at the reasons for limitation in performance. Consider an infinitesimal dipole of frequency v in front of a lens. The electric component of the field will be given by some 2D Fourier expansion,

/pdf/negative-refraction-makes-a-perfect-lens-2yepsrmjen.pdf

Negative Refraction Makes a Perfect Lens

Using the freedom of design that metamaterials provide, we show how electromagnetic fields can be redirected at will and propose a design strategy. The conserved fields-electric displacement field D, magnetic induction field B, and Poynting vector B-are all displaced in a consistent manner. A simple illustration is given of the cloaking of a proscribed volume of space to exclude completely all electromagnetic fields. Our work has relevance to exotic lens design and to the cloaking of objects from electromagnetic fields.

/pdf/controlling-electromagnetic-fields-3ryxkryf1t.pdf

Controlling Electromagnetic Fields

A recently published theory has suggested that a cloak of invisibility is in principle possible, at least over a narrow frequency band. We describe here the first practical realization of such a cloak; in our demonstration, a copper cylinder was "hidden" inside a cloak constructed according to the previous theoretical prescription. The cloak was constructed with the use of artificially structured metamaterials, designed for operation over a band of microwave frequencies. The cloak decreased scattering from the hidden object while at the same time reducing its shadow, so that the cloak and object combined began to resemble empty space.

/pdf/metamaterial-electromagnetic-cloak-at-microwave-frequencies-1qj4zdgl8e.pdf

Metamaterial Electromagnetic Cloak at Microwave Frequencies

The plasmon is a well established collective excitation of metals in the visible and near UV, but at much lower frequencies dissipation destroys all trace of the plasmon and typical Drude behavior sets in. We propose a mechanism for depression of the plasma frequency into the far infrared or even GHz band: Periodic structures built of very thin wires dilute the average concentration of electrons and considerably enhance the effective electron mass through self-inductance. Computations replicate the key features and confirm our analytic theory. The new structure has novel properties not observed before in the GHz band, including some possible impact on superconducting properties.

/pdf/extremely-low-frequency-plasmons-in-metallic-mesostructures-2zuwg2ikto.pdf

John B. Pendry

Papers

Negative Refraction Makes a Perfect Lens

Magnetism from conductors and enhanced nonlinear phenomena

Controlling Electromagnetic Fields

Metamaterial Electromagnetic Cloak at Microwave Frequencies

Extremely Low Frequency Plasmons in Metallic Mesostructures