抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Surface plasmons are waves that propagate along the surface of a conductor. By altering the structure of a metal's surface, the properties of surface plasmons--in particular their interaction with light--can be tailored, which offers the potential for developing new types of photonic device. This could lead to miniaturized photonic circuits with length scales that are much smaller than those currently achieved. Surface plasmons are being explored for their potential in subwavelength optics, data storage, light generation, microscopy and bio-photonics.

/pdf/surface-plasmon-subwavelength-optics-5e55p12p4o.pdf

Surface plasmon subwavelength optics

We present experimental scattering data at microwave frequencies on a structured metamaterial that exhibits a frequency band where the effective index of refraction (n) is negative. The material consists of a two-dimensional array of repeated unit cells of copper strips and split ring resonators on interlocking strips of standard circuit board material. By measuring the scattering angle of the transmitted beam through a prism fabricated from this material, we determine the effective n, appropriate to Snell's law. These experiments directly confirm the predictions of Maxwell's equations that n is given by the negative square root of epsilon.mu for the frequencies where both the permittivity (epsilon) and the permeability (mu) are negative. Configurations of geometrical optical designs are now possible that could not be realized by positive index materials.

/pdf/experimental-verification-of-a-negative-index-of-refraction-37hlxn3tta.pdf

Experimental Verification of a Negative Index of Refraction

We show that microstructures built from nonmagnetic conducting sheets exhibit an effective magnetic permeability /spl mu//sub eff/, which can be tuned to values not accessible in naturally occurring materials, including large imaginary components of /spl mu//sub eff/. The microstructure is on a scale much less than the wavelength of radiation, is not resolved by incident microwaves, and uses a very low density of metal so that structures can be extremely lightweight. Most of the structures are resonant due to internal capacitance and inductance, and resonant enhancement combined with compression of electrical energy into a very small volume greatly enhances the energy density at critical locations in the structure, easily by factors of a million and possibly by much more. Weakly nonlinear materials placed at these critical locations will show greatly enhanced effects raising the possibility of manufacturing active structures whose properties can be switched at will between many states.

/pdf/magnetism-from-conductors-and-enhanced-nonlinear-phenomena-2fpnoamwae.pdf

Magnetism from conductors and enhanced nonlinear phenomena

The emerging field of plasmonics has yielded methods for guiding and localizing light at the nanoscale, well below the scale of the wavelength of light in free space. Now plasmonics researchers are turning their attention to photovoltaics, where design approaches based on plasmonics can be used to improve absorption in photovoltaic devices, permitting a considerable reduction in the physical thickness of solar photovoltaic absorber layers, and yielding new options for solar-cell design. In this review, we survey recent advances at the intersection of plasmonics and photovoltaics and offer an outlook on the future of solar cells based on these principles.

Plasmonics for improved photovoltaic devices

We investigate the transmission of evanescent waves through a slab of photonic crystal and explore the recently suggested possibility of focusing light with subwavelength resolution. The amplification of near-field waves is shown to rely on resonant coupling mechanisms to surface photon bound states, and the negative refractive index is only one way of realizing this effect. It is found that the periodicity of the photonic crystal imposes an upper cutoff to the transverse wave vector of evanescent waves that can be amplified, and thus a photonic-crystal superlens is free of divergences even in the lossless case. A detailed numerical study of the optical image of such a superlens in two dimensions reveals a subtle and very important interplay between propagating waves and evanescent waves on the final image formation. Particular features that arise due to the presence of near-field light are discussed.

/pdf/subwavelength-imaging-in-photonic-crystals-1cessc1emt.pdf

Subwavelength imaging in photonic crystals

Theory of photoemission

On the basis of conformal transformation, a general strategy is proposed to design plasmonic nanostructures capable of an efficient harvesting of light over a broadband spectrum. The surface plasmon modes propagate toward the singularity of these structures where the group velocity vanishes and energy accumulates. A considerable field enhancement and confinement is thus expected. Radiation losses are also investigated when the structure dimension becomes comparable to the wavelength.

/pdf/plasmonic-light-harvesting-devices-over-the-whole-visible-3kpccislri.pdf

Plasmonic light-harvesting devices over the whole visible spectrum.

It is shown that the surface barrier potential can confine electrons in surface states, which because of the coulombic tail on the potential form a Rydberg series. This previously known result is made more rigorous by a discussion of lifetime broadening of the states. Observability of the states via LEED experiments is also investigated. The Rydberg series should give rise to structure in LEED curves which can in principle be resolved for all members of the series as n to infinity .

https://iopscience.iop.org/article/10.1088/0022-3719/11/10/017/pdf

The existence and detection of Rydberg states at surfaces

Recently it has been proposed that a planar slab of material, for which both the permittivity and permeability have the values of -1, could bring not only the propagating fields associated with a source to a focus, but could also refocus the nonpropagating near-fields, thereby achieving a subdiffraction image. In this work we discuss the sensitivity of the subwavelength focus to various slab parameters, pointing out the connection to slab plasmon modes. We also note and resolve a paradox associated with the perfect imaging of a point source. We conclude that subwavelength resolution is achievable with available technology, but only by implementation of a critical set of design parameters.

John B. Pendry

Papers

Subwavelength imaging in photonic crystals

Theory of photoemission

Plasmonic light-harvesting devices over the whole visible spectrum.

The existence and detection of Rydberg states at surfaces

Limitations on Sub-Diffraction Imaging with a Negative Refractive Index Slab