J
John Bowes
Researcher at University of Manchester
Publications - 132
Citations - 11574
John Bowes is an academic researcher from University of Manchester. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 42, co-authored 105 publications receiving 10341 citations. Previous affiliations of John Bowes include Royal National Hospital for Rheumatic Diseases & National Health Service.
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Journal ArticleDOI
Genetics of rheumatoid arthritis contributes to biology and drug discovery
Yukinori Okada,Yukinori Okada,Di Wu,Di Wu,Di Wu,Gosia Trynka,Gosia Trynka,Towfique Raj,Towfique Raj,Chikashi Terao,Katsunori Ikari,Yuta Kochi,Koichiro Ohmura,Akari Suzuki,Shinji Yoshida,Robert R. Graham,A. Manoharan,Ward Ortmann,Tushar Bhangale,Joshua C. Denny,Robert J. Carroll,Anne E. Eyler,Jeff Greenberg,Joel M. Kremer,Dimitrios A. Pappas,Lei Jiang,Jian Yin,Lingying Ye,Ding Feng Su,Jian Yang,Gang Xie,E.C. Keystone,Harm-Jan Westra,Tõnu Esko,Tõnu Esko,Tõnu Esko,Andres Metspalu,Xuezhong Zhou,Namrata Gupta,Daniel B. Mirel,Eli A. Stahl,Dorothee Diogo,Dorothee Diogo,Jing Cui,Jing Cui,Katherine P. Liao,Katherine P. Liao,Michael H. Guo,Michael H. Guo,Keiko Myouzen,Takahisa Kawaguchi,Marieke J H Coenen,Piet L. C. M. van Riel,Mart A F J van de Laar,Henk-Jan Guchelaar,Tom W J Huizinga,Philippe Dieudé,Xavier Mariette,S. Louis Bridges,Alexandra Zhernakova,Alexandra Zhernakova,René E. M. Toes,Paul P. Tak,Paul P. Tak,Paul P. Tak,Corinne Miceli-Richard,So Young Bang,Hye Soon Lee,Javier Martin,Miguel A. Gonzalez-Gay,Luis Rodriguez-Rodriguez,Solbritt Rantapää-Dahlqvist,Lisbeth Ärlestig,Hyon K. Choi,Hyon K. Choi,Yoichiro Kamatani,Pilar Galan,Mark Lathrop,Steve Eyre,Steve Eyre,John Bowes,John Bowes,Anne Barton,Niek de Vries,Larry W. Moreland,Lindsey A. Criswell,Elizabeth W. Karlson,Atsuo Taniguchi,Ryo Yamada,Michiaki Kubo,Jun Liu,Sang Cheol Bae,Jane Worthington,Jane Worthington,Leonid Padyukov,Lars Klareskog,Peter K. Gregersen,Soumya Raychaudhuri,Soumya Raychaudhuri,Barbara E. Stranger,Philip L. De Jager,Philip L. De Jager,Lude Franke,Peter M. Visscher,Matthew A. Brown,Hisashi Yamanaka,Tsuneyo Mimori,Atsushi Takahashi,Huji Xu,Timothy W. Behrens,Katherine A. Siminovitch,Shigeki Momohara,Fumihiko Matsuda,Kazuhiko Yamamoto,Robert M. Plenge,Robert M. Plenge +115 more
TL;DR: A genome-wide association study meta-analysis in a total of >100,000 subjects of European and Asian ancestries provides empirical evidence that the genetics of RA can provide important information for drug discovery, and sheds light on fundamental genes, pathways and cell types that contribute to RA pathogenesis.
Journal ArticleDOI
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
Eli A. Stahl,Soumya Raychaudhuri,Soumya Raychaudhuri,Elaine F. Remmers,Gang Xie,Stephen Eyre,Brian Thomson,Yonghong Li,Fina A S Kurreeman,Fina A S Kurreeman,Fina A S Kurreeman,Alexandra Zhernakova,Anne Hinks,Candace Guiducci,Robert Chen,Lars Alfredsson,Christopher I. Amos,Kristin G. Ardlie,Anne Barton,John Bowes,Elisabeth Brouwer,Noël P. Burtt,Joseph J. Catanese,Jonathan S. Coblyn,Marieke J H Coenen,Karen H. Costenbader,Lindsey A. Criswell,J. Bart A. Crusius,Jing Cui,Paul I.W. de Bakker,Paul I.W. de Bakker,Philip L. De Jager,Philip L. De Jager,Bo Ding,Paul Emery,Edward Flynn,Pille Harrison,Lynne J. Hocking,Tom W J Huizinga,Daniel L. Kastner,Xiayi Ke,Annette Lee,Xiangdong Liu,Paul Martin,Ann W. Morgan,Leonid Padyukov,Marcel D. Posthumus,Timothy R D J Radstake,David M. Reid,Mark Seielstad,Michael F. Seldin,Nancy A. Shadick,Sophia Steer,Paul P. Tak,Wendy Thomson,Annette H M van der Helm-van Mil,Irene E. van der Horst-Bruinsma,C. Ellen van der Schoot,Piet L. C. M. van Riel,Michael E. Weinblatt,Anthony G. Wilson,Gertjan Wolbink,B. Paul Wordsworth,Cisca Wijmenga,Elizabeth W. Karlson,René E. M. Toes,Niek de Vries,Ann B. Begovich,Ann B. Begovich,Jane Worthington,Katherine A. Siminovitch,Peter K. Gregersen,Lars Klareskog,Robert M. Plenge,Robert M. Plenge +74 more
TL;DR: Seven new rheumatoid arthritis risk alleles were identified at genome-wide significance (P < 5 × 10−8) in an analysis of all 41,282 samples, and an additional 11 SNPs replicated at P < 0.05, suggesting that most represent genuine rhearatoid arthritisrisk alleles.
Journal ArticleDOI
Correction: Corrigendum: Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis
John Bowes,Ashley Budu-Aggrey,Ulrike Hüffmeier,Steffen Uebe,Kathryn J. A. Steel,Harry L. Hébert,Chris Wallace,Jonathon Massey,Ian N. Bruce,James Bluett,Marie Feletar,Ann W. Morgan,Helena Marzo-Ortega,Gary Donohoe,Derek W. Morris,Philip S. Helliwell,Anthony W. Ryan,David Kane,Richard B. Warren,Eleanor Korendowych,Gerd-Marie Alenius,Emiliano Giardina,Jonathan Packham,Ross McManus,Oliver FitzGerald,Neil McHugh,Matthew A. Brown,Pauline Ho,Frank Behrens,Harald Burkhardt,André Reis,Anne Barton +31 more
TL;DR: This work presents a novel and scalable approach to genome-based approaches that combines cell reprograming, nanofiltration, and ‘spatially aggregating’ techniques that allow for real-time assessment of the impact of environmental factors on gene expression and disease progression.
Journal ArticleDOI
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls
Nicholas John Craddock,Matthew E. Hurles,Niall Cardin,Richard D. Pearson,Vincent Plagnol,Samuel Robson,Damjan Vukcevic,Chris P. Barnes,Donald F. Conrad,Eleni Giannoulatou,Christopher Holmes,Jonathan Marchini,Kathy Stirrups,Martin D. Tobin,Louise V. Wain,Christopher Yau,Jan Aerts,Tariq Ahmad,T. Daniel Andrews,Hazel Arbury,Anthony Attwood,Anthony Attwood,Anthony Attwood,Adam Auton,Stephen G. Ball,Anthony J. Balmforth,Jeffrey C. Barrett,Inês Barroso,Anne Barton,Amanda J. Bennett,Sanjeev S. Bhaskar,Katarzyna Blaszczyk,John Bowes,Oliver J. Brand,Peter S. Braund,Francesca Bredin,Gerome Breen,Gerome Breen,Morris J. Brown,Ian N. Bruce,Jaswinder Bull,Oliver S. Burren,John Burton,Jake K. Byrnes,Sian Caesar,Chris Clee,Alison J. Coffey,John M. C. Connell,Jason D. Cooper,Anna F. Dominiczak,Kate Downes,Hazel E. Drummond,Darshna Dudakia,Andrew Dunham,Bernadette Ebbs,Diana Eccles,Sarah Edkins,Cathryn Edwards,Anna Elliot,Paul Emery,David M. Evans,Gareth Evans,Steve Eyre,Anne Farmer,I. Nicol Ferrier,Lars Feuk,Lars Feuk,Tomas W Fitzgerald,Edward Flynn,Alistair Forbes,Liz Forty,Jayne A. Franklyn,Jayne A. Franklyn,Rachel M. Freathy,Polly Gibbs,Paul Gilbert,Omer Gokumen,Katherine Gordon-Smith,Katherine Gordon-Smith,Emma Gray,Elaine K. Green,Christopher J. Groves,Detelina Grozeva,Rhian Gwilliam,A Hall,Naomi Hammond,Matthew Hardy,Pile Harrison,Neelam Hassanali,Husam Hebaishi,Sarah Hines,Anne Hinks,Graham A. Hitman,Lynne J. Hocking,Eleanor Howard,Philip Howard,Joanna M. M. Howson,Debbie Hughes,Sarah E. Hunt,John D. Isaacs,Mahim Jain,Derek P. Jewell,Toby Johnson,Jennifer Jolley,Jennifer Jolley,Ian Jones,Lisa Jones,George Kirov,Cordelia Langford,Hana Lango-Allen,G. Mark Lathrop,James Lee,Kate L. Lee,Charlie W. Lees,Kevin Lewis,Cecilia M. Lindgren,Meeta Maisuria-Armer,Julian Maller,John C. Mansfield,Paul Martin,Dunecan Massey,Wendy L. McArdle,Peter McGuffin,Kirsten McLay,Alexander J. Mentzer,Michael L. Mimmack,Ann E. Morgan,Andrew P. Morris,Craig Mowat,Simon Myers,William G. Newman,Elaine R. Nimmo,Michael Conlon O'Donovan,Abiodun Onipinla,Ifejinelo Onyiah,Nigel R. Ovington,Michael John Owen,Kimmo Palin,Kirstie Parnell,David Pernet,John R. B. Perry,Anne M. Phillips,Dalila Pinto,Natalie J. Prescott,Inga Prokopenko,Michael A. Quail,Suzanne Rafelt,Nigel W. Rayner,Richard Redon,David M. Reid,Anthony Renwick,Susan M. Ring,Neil Robertson,E. Russell,David St Clair,Jennifer G. Sambrook,Jennifer G. Sambrook,Jeremy D. Sanderson,Helen Schuilenburg,Carol Scott,Richard T. Scott,Sheila Seal,Sue Shaw-Hawkins,Beverley M. Shields,Matthew J. Simmonds,Debbie J. Smyth,Elilan Somaskantharajah,Katarina Spanova,Sophia Steer,Jonathan Stephens,Jonathan Stephens,Helen Stevens,Millicent A. Stone,Millicent A. Stone,Zhan Su,Deborah P M Symmons,John R. Thompson,Wendy Thomson,Mary E. Travers,Clare Turnbull,Armand Valsesia,Mark Walker,Neil Walker,Chris Wallace,Margaret Warren-Perry,Nicholas A. Watkins,Nicholas A. Watkins,John Webster,Michael N. Weedon,Anthony G. Wilson,Matthew Woodburn,B. Paul Wordsworth,Allan H. Young,Allan H. Young,Eleftheria Zeggini,Eleftheria Zeggini,Nigel P. Carter,Timothy M. Frayling,Charles Lee,Gil McVean,Patricia B. Munroe,Aarno Palotie,Stephen Sawcer,Stephen W. Scherer,David P. Strachan,Chris Tyler-Smith,Matthew A. Brown,Matthew A. Brown,Paul Burton,Mark J. Caulfield,Alastair Compston,Martin Farrall,Stephen C. L. Gough,Stephen C. L. Gough,Alistair S. Hall,Andrew T. Hattersley,Adrian V. S. Hill,Christopher G. Mathew,Marcus Pembrey,Jack Satsangi,Michael R. Stratton,Jane Worthington,Panos Deloukas,Audrey Duncanson,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski,Mark I. McCarthy,Willem H. Ouwehand,Willem H. Ouwehand,Willem H. Ouwehand,Miles Parkes,Nazneen Rahman,John A. Todd,Nilesh J. Samani,Nilesh J. Samani,Peter Donnelly +235 more
TL;DR: A large, direct genome-wide study of association between CNVs and eight common human diseases concludes that common CNVs that can be typed on existing platforms are unlikely to contribute greatly to the genetic basis ofcommon human diseases.
Journal ArticleDOI
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis
Steve Eyre,John Bowes,John Bowes,Dorothée Diogo,Dorothée Diogo,Annette Lee,Anne Barton,Anne Barton,Paul Martin,Paul Martin,Alexandra Zhernakova,Alexandra Zhernakova,Eli A. Stahl,Eli A. Stahl,Sebastien Viatte,Sebastien Viatte,Kate McAllister,Kate McAllister,Christopher I. Amos,Leonid Padyukov,René E. M. Toes,Tom W J Huizinga,Cisca Wijmenga,Gosia Trynka,Lude Franke,Harm-Jan Westra,Lars Alfredsson,Xinli Hu,Cynthia Sandor,Cynthia Sandor,Paul I.W. de Bakker,Sonia Davila,Chiea Chuen Khor,Khai Koon Heng,Robert Andrews,Sarah Edkins,Sarah E. Hunt,Cordelia Langford,Deborah P M Symmons,Deborah P M Symmons,Genomics Study Syndicate,Patrick Concannon,Suna Onengut-Gumuscu,Stephen S. Rich,Panos Deloukas,Miguel A. Gonzalez-Gay,Luis Rodriguez-Rodriguez,Lisbeth Ärlsetig,Javier Martin,Solbritt Rantapää-Dahlqvist,Robert M. Plenge,Robert M. Plenge,Soumya Raychaudhuri,Lars Klareskog,Peter K. Gregersen,Jane Worthington,Jane Worthington +56 more
TL;DR: This study illustrates the advantages of dense SNP mapping analysis to inform subsequent functional investigations and refined the peak of association to a single gene for 19 loci, identified secondary independent effects at 6 loci and identified association to low-frequency variants at 4 loci.