John C. Burnett

TL;DR: In the community, systolic dysfunction is frequently present in individuals without recognized CHF and diastolic dysfunction as rigorously defined by comprehensive Doppler techniques is common, often not accompanied by recognizedCHF, and associated with marked increases in all-cause mortality.

TL;DR: Investigation of the effects of age and gender on plasma brain natriuretic peptide concentration in a population-based study confirmed that discriminatory values for BNP for detection of reduced ejection fraction were higher in women and older persons and were different between the two assays.

TL;DR: In this article, the prevalence of diastolic dysfunction and its relation to systolic dysfunction in the community were determined by a Doppler echocardiographic assessment.

TL;DR: An elevated plasma BNP was a more powerful marker ofleft ventricular systolic dysfunction, left ventricular diastolic function and left vent cardiac hypertrophy than C-terminal ANP or N-terminAL ANP-(1-30) in this population of patients with suspected cardiac disease.

TL;DR: Amino-terminal pro-BNP in normal patients is affected primarily by gender and age, which should be considered when interpreting values, and in the entire population sample NT-proBNP performed at least equivalently to BNP in detecting LV dysfunction and was superior in some subgroups in detectingLV systolic dysfunction.