J
John C. Cambier
Researcher at University of Colorado Denver
Publications - 323
Citations - 24087
John C. Cambier is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: B cell & Signal transduction. The author has an hindex of 83, co-authored 323 publications receiving 22708 citations. Previous affiliations of John C. Cambier include American Cyanamid & Colorado State University.
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Journal ArticleDOI
Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production
Michael J. White,Michael J. White,Kate McArthur,Kate McArthur,Donald Metcalf,Donald Metcalf,Rachael M. Lane,John C. Cambier,Marco J Herold,Marco J Herold,Mark F. van Delft,Mark F. van Delft,Sammy Bedoui,Guillaume Lessene,Guillaume Lessene,Matthew E. Ritchie,Matthew E. Ritchie,David C.S. Huang,David C.S. Huang,Benjamin T. Kile,Benjamin T. Kile +20 more
TL;DR: The apoptotic caspase cascade functions to render mitochondrial apoptosis immunologically silent, and suppresses type I interferon (IFN) production by cells undergoing Bak/Bax-mediated apoptosis.
Journal ArticleDOI
B cell antigen receptor signaling 101.
Joseph M. Dal Porto,Stephen B. Gauld,Kevin T. Merrell,David M. Mills,Aimee E. Pugh-Bernard,John C. Cambier +5 more
TL;DR: All cells continually survey their environment and make decisions based on cues encountered, where signals transmitted by the B cell Ag-receptor influence not only cellular selection, maturation, and survival, but are imperative in generating the ultimate effector function of B cells, i.e. antibody production.
Journal ArticleDOI
Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by Fc gamma RIIB1.
Daniele D'Ambrosio,Keli L. Hippen,Stacey A. Minskoff,Ira Mellman,Giovanni Pani,Kathy Siminovitch,John C. Cambier +6 more
TL;DR: It was shown that the Fc gamma RIIB1 recruits the phosphotyrosine phosphatase PTP1C after BCR coligation, and this association is mediated by the binding of a 13-amino acid tyrosine-phosphorylated sequence to the carboxyl-terminal Src homology 2 domain of PTP 1C and activates P TP1C.
Journal ArticleDOI
Hypoxia-inducible factor-1 alpha–dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa
Eric T. Clambey,Eóin N. McNamee,Joseph A. Westrich,Louise E. Glover,Eric L. Campbell,Paul Jedlicka,Edwin F. de Zoeten,John C. Cambier,Kurt R. Stenmark,Sean P. Colgan,Holger K. Eltzschig +10 more
TL;DR: It is demonstrated that hypoxia is an intrinsic molecular cue that promotes FoxP3 expression, in turn eliciting potent anti-inflammatory mechanisms to limit tissue damage in conditions of reduced oxygen availability.