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John C. Chatham

Researcher at University of Alabama at Birmingham

Publications -  190
Citations -  15192

John C. Chatham is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Carbohydrate metabolism & Autophagy. The author has an hindex of 59, co-authored 182 publications receiving 13692 citations. Previous affiliations of John C. Chatham include Johns Hopkins University & Henry Ford Health System.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Alterations in Liver ATP Homeostasis in Human Nonalcoholic Steatohepatitis: A Pilot Study

Helena Cortez-Pinto, +5 more
- 03 Nov 1999 - 
TL;DR: Recovery from hepatic ATP depletion becomes progressively less efficient as body mass increases in healthy controls and is severely impaired in patients with obesity-related nonalcoholic steatohepatitis.
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Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion.

Kenneth D. Chavin, +12 more
- 26 Feb 1999 - 
TL;DR: In situ hybridization and immunohistochemical analysis of ob/ob livers demonstrate that U CP2 mRNA and protein expression are increased in hepatocytes, which do not express UCP2 in lean mice, and hepatocytes adapt to obesity by up-regulating UCP1.
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Assessing bioenergetic function in response to oxidative stress by metabolic profiling

Brian P. Dranka, +11 more
- 01 Nov 2011 - 
TL;DR: Methods for assessing the impact of reactive species on isolated mitochondria are described using representative cell types from renal, cardiovascular, nervous, and tumorigenic model systems while illustrating the application of three protocols to analyze the bioenergetic response of cells to oxidative stress.
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Quantitation of proton NMR spectra of the human brain using tissue water as an internal concentration reference

Peter B. Barker, +5 more
- 01 Jan 1993 - 
TL;DR: Using cerebral water as an internal intensity standard for the quantitation of spatially localized proton spectra of the human brain is investigated, and choline and creatine concentrations are in good agreement with conventional biochemical values.