J
John D. Toft
Researcher at Battelle Memorial Institute
Publications - 8
Citations - 421
John D. Toft is an academic researcher from Battelle Memorial Institute. The author has contributed to research in topics: Cell & Heinz body. The author has an hindex of 7, co-authored 8 publications receiving 406 citations.
Papers
More filters
Journal ArticleDOI
Comparative Carcinogenicity in Sprague–Dawley Rats of the Polychlorinated Biphenyl Mixtures Aroclors 1016, 1242, 1254, and 1260
Brian A. Mayes,E. E. McConnell,B. H. Neal,MJ Brunner,Stephen B. Hamilton,TM Sullivan,A. C. Peters,Michael J. Ryan,John D. Toft,A. W. Singer,Jr Jf Brown,RG Menton,JA Moore +12 more
TL;DR: Liver toxicity was distinctly more severe in females than in males, and the incidence of hepatocellular neoplasms was highly sex-dependent (females > males), differed between Aroclor mixtures and, for females, increased with dose and followed the general incidence pattern.
Journal ArticleDOI
Results and conclusions of the National Toxicology Program's rodent carcinogenicity studies with sodium fluoride.
John R. Bucher,Milton R. Hejtmancik,John D. Toft,Ronald L. Persing,Scot L. Eustis,Joseph K. Haseman +5 more
TL;DR: There was equivocal evidence of carcinogenic activity of sodium fluoride in male rats based on the occurrence of a small number of osteosarcomas in treated animals, and female rats given 175 ppm had increased osteosclerosis.
Journal ArticleDOI
Toxicology and carcinogenesis studies of pentachlorophenol in rats
Rajendra S. Chhabra,R M Maronpot,John R. Bucher,Joseph K. Haseman,John D. Toft,Milton R. Hejtmancik +5 more
TL;DR: There was no evidence of carcinogenic activity of PCP in male or female rats fed diets containing 200, 400, or 600 ppm for 2 years, and stop-exposure study males and females regained a transitory body weight reduction by the end of the 2 year study, and males had better survival than the controls.
Book ChapterDOI
Chapter 3 – Parasitic Diseases
John D. Toft,Mark L. Eberhard +1 more
TL;DR: The histomorphologic features of protozoan and metazoan parasitic infections of nonhuman primates were discussed in this article, and several diseases caused by protozooan parasites such as flagellates, sarcodines, Apicomplexa, microsporidia, ciliates, and Pneumocystis were discussed.
Journal ArticleDOI
Hematological effects in F344 rats and B6C3F1 mice during the 13-week gavage toxicity study of methylene blue trihydrate
Milton R. Hejtmancik,Michael J. Ryan,John D. Toft,Ronald L. Persing,P. J. Kurtz,Rajendra S. Chhabra +5 more
TL;DR: Mice appeared to be more sensitive than rats to the formation of Heinz bodies and the development of anemia that was characterized by a decrease in hemoglobin, hematocrit, and erythrocyte count, and a dose-related increase in the reticulocyte count suggested a compensatory response to anemia.