J
John E. Deanfield
Researcher at University College London
Publications - 529
Citations - 67990
John E. Deanfield is an academic researcher from University College London. The author has contributed to research in topics: Endothelial dysfunction & Population. The author has an hindex of 120, co-authored 497 publications receiving 61067 citations. Previous affiliations of John E. Deanfield include Barts Health NHS Trust & UCL Institute of Child Health.
Papers
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Journal ArticleDOI
Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis
David S. Celermajer,Keld E. Sørensen,V.M. Gooch,David Spiegelhalter,Owen Miller,Ian D. Sullivan,J.K. Lloyd,John E. Deanfield +7 more
TL;DR: Endothelial dysfunction is present in children and adults with risk factors for atherosclerosis, such as smoking and hypercholesterolaemia, before anatomical evidence of plaque formation in the arteries studied, suggesting this may be an important early event in atherogenesis.
Journal ArticleDOI
Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: A report of the International Brachial Artery Reactivity Task Force
Mary C. Corretti,Todd J. Anderson,Emelia J. Benjamin,David S. Celermajer,Francois Charbonneau,Mark A. Creager,John E. Deanfield,Helmut Drexler,Marie Gerhard-Herman,David M. Herrington,Patrick Vallance,Joseph A. Vita,Robert A. Vogel +12 more
TL;DR: State-of-the-art information is presented and insights are provided into the strengths and limitations of high-resolution ultrasonography of the brachial artery to evaluate vasomotor function, with guidelines for its research application in the study of endothelial physiology.
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Endothelial Function and Dysfunction Testing and Clinical Relevance
TL;DR: Current understanding of endothelial biology in health and disease, the strengths and weaknesses of current testing strategies, and their potential applications in clinical research and patient care are summarized.
Journal ArticleDOI
Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults.
David S. Celermajer,Keld E. Sørensen,Dimitri Georgakopoulos,Catherine Bull,Odette Thomas,Jacqui Robinson,John E. Deanfield +6 more
TL;DR: Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent arterial dilation in asymptomatic young adults, consistent with endothelial dysfunction.
Journal ArticleDOI
Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women
David S. Celermajer,Keld E. Sørensen,David Spiegelhalter,Dimitri Georgakopoulos,Jacqui Robinson,John E. Deanfield +5 more
TL;DR: Age-related decline in vascular health is associated with progressive endothelial dysfunction in normal humans, and this appears to occur earlier in men than in women, but in women a steep decline commences at around the time of the menopause, consistent with a protective effect of estrogens on the arterial wall.