J
John Eid
Researcher at Pacific Biosciences
Publications - 45
Citations - 6478
John Eid is an academic researcher from Pacific Biosciences. The author has contributed to research in topics: Microbiome & Butyrate. The author has an hindex of 20, co-authored 43 publications receiving 5904 citations. Previous affiliations of John Eid include Boston University & University of Illinois at Urbana–Champaign.
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Journal ArticleDOI
Real-Time DNA Sequencing from Single Polymerase Molecules
John Eid,Adrian Fehr,Jeremy Gray,Khai Luong,John Lyle,Geoff Otto,Paul Peluso,David R. Rank,Primo Baybayan,Brad Bettman,Arkadiusz Bibillo,Keith Bjornson,Bidhan Chaudhuri,Fred Christians,Ronald L. Cicero,Sonya Clark,Ravindra V. Dalal,Alex DeWinter,John Dixon,Mathieu Foquet,Alfred Gaertner,Paul Hardenbol,Cheryl Heiner,Kevin Hester,David P. Holden,Gregory J. Kearns,Xiangxu Kong,Ronald Kuse,Yves Lacroix,Steven Lin,Paul Lundquist,Congcong Ma,Patrick Marks,Mark Maxham,Devon Murphy,Insil Park,Thang Pham,Michael Phillips,Joy Roy,Robert Sebra,Gene Shen,Jon M. Sorenson,Austin B. Tomaney,Kevin Travers,Mark Trulson,John Vieceli,Jeffrey Wegener,Dawn Wu,Alicia Yang,Denis Zaccarin,Peter Zhao,Frank Zhong,Jonas Korlach,Stephen Turner +53 more
TL;DR: Single-molecule, real-time sequencing data obtained from a DNA polymerase performing uninterrupted template-directed synthesis using four distinguishable fluorescently labeled deoxyribonucleoside triphosphates (dNTPs) are presented.
Journal ArticleDOI
Origins of the E. coli Strain Causing an Outbreak of Hemolytic–Uremic Syndrome in Germany
David A. Rasko,Dale R. Webster,Jason W. Sahl,Ali Bashir,Nadia Boisen,Flemming Scheutz,Ellen E. Paxinos,Robert Sebra,Chen-Shan Chin,Dimitris Iliopoulos,Aaron Klammer,Paul Peluso,Lawrence Lee,Andrey Kislyuk,James H. Bullard,Andrew Kasarskis,Susanna Wang,John Eid,David R. Rank,Julia C. Redman,Susan R. Steyert,Jakob Frimodt-Møller,Carsten Struve,Andreas Petersen,Karen A. Krogfelt,James P. Nataro,Eric E. Schadt,Matthew K. Waldor +27 more
TL;DR: The findings suggest that horizontal genetic exchange allowed for the emergence of the highly virulent Shiga-toxin-producing enteroaggregative E. coli O104:H4 strain that caused the German outbreak, and highlight the way in which the plasticity of bacterial genomes facilitates the emerged of new pathogens.
Journal ArticleDOI
A flexible and efficient template format for circular consensus sequencing and SNP detection
TL;DR: The generation of high-quality consensus accuracy from single molecules, as well as the use of SMRTbell templates in the identification of rare sequence variants are demonstrated.
Journal ArticleDOI
Comparative analysis of tandem repeats from hundreds of species reveals unique insights into centromere evolution.
Daniël P. Melters,Keith Bradnam,Hugh A. Young,Natalie Telis,Michael R. May,J. Graham Ruby,Robert Sebra,Paul Peluso,John Eid,David R. Rank,José Fernando Garcia,Joseph L. DeRisi,Joseph L. DeRisi,Timothy P. L. Smith,Christian M. Tobias,Jeffrey Ross-Ibarra,Ian F Korf,Simon W. L. Chan,Simon W. L. Chan +18 more
TL;DR: The results indicate that tandem repeats are highly prevalent at centromeres of both animal and plant genomes, which suggests a functional role for such repeats, perhaps in promoting concerted evolution of centromere DNA across chromosomes.
Journal ArticleDOI
Sequencing the unsequenceable: Expanded CGG-repeat alleles of the fragile X gene
Erick Loomis,John Eid,Paul Peluso,Jun Yin,Luke Hickey,David R. Rank,Sarah McCalmon,Randi J Hagerman,Flora Tassone,Paul J. Hagerman +9 more
TL;DR: This kinetic signature reveals a novel aspect of the repeat element; namely, that the particular G bias within the CGG/CCG-repeat element influences polymerase activity in a manner that extends beyond simple nearest-neighbor effects.