J
John Ellis
Researcher at University of Birmingham
Publications - 24
Citations - 1378
John Ellis is an academic researcher from University of Birmingham. The author has contributed to research in topics: Nitroreductase & Population. The author has an hindex of 10, co-authored 20 publications receiving 1348 citations.
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Journal ArticleDOI
Natural history of cervical human papillomavirus infection in young women: a longitudinal cohort study
Ciaran B J Woodman,Stuart Collins,Heather Winter,Andrew Bailey,John Ellis,Pat Prior,Marie Yates,Terry P. Rollason,Lawrence S. Young +8 more
TL;DR: The findings suggest that attempts to exploit the association between cervical neoplasia and HPV infection to improve effectiveness of cervical screening programmes might be undermined by the limited inferences that can be drawn from the characterisation of a woman's HPV status at a single point in time, and the short lead time gained by its detection.
Journal ArticleDOI
The association of an HPV16 oncogene variant with HLA-B7 has implications for vaccine design in cervical cancer.
John Ellis,Patrick Keating,J Baird,Elizabeth F. Hounsell,David V. Renouf,Martin Rowe,D Hopkins,Margaret F Duggan-Keen,Jennifer S. Bartholomew,Lawrence S. Young,Peter L. Stern +10 more
TL;DR: A biologically relevant mechanism for escape from immune surveillance of HPV16 in HLA-B7 individuals is identified and both HLA type and HPV16 strain variation need to be considered in the screening of at-risk individuals and for the rational design of anti-HPV vaccines.
Journal ArticleDOI
Virus-directed enzyme prodrug therapy : intratumoral administration of a replication-deficient adenovirus encoding nitroreductase to patients with resectable liver cancer
Daniel H. Palmer,Vivien Mautner,Darius F. Mirza,Simon Oliff,Winald R. Gerritsen,Joost R.M. van der Sijp,Stefan G. Hubscher,Gary M. Reynolds,Sarah Bonney,Ratna Rajaratnam,Diana Hull,Mark Horne,John Ellis,Andrew Mountain,Simon Hill,Peter A. Harris,Peter F. Searle,Lawrence S. Young,Nicholas D. James,David J. Kerr +19 more
TL;DR: Direct intratumoral inoculation of CTL102 to patients with primary and secondary liver cancer is feasible and well tolerated and the high level of nitroreductase expression observed at 1 to 5 x 10(11) virus particles mandates further studies in patients with inoperable tumors who will receive CTL 102 and CB1954.
Journal ArticleDOI
Eye disease associated with handling pet tarantulas: three case reports
TL;DR: Three cases of ocular injury from urticarious hairs of tarantulas are described, with the main findings of multiple fine intracorneal hairs with an associated keratoconjunctivitis.
Journal ArticleDOI
Gene therapy and cement injection for restabilization of loosened hip prostheses.
Jolanda J. de Poorter,Rob C. Hoeben,Simone Hogendoorn,Vivien Mautner,John Ellis,Wim R. Obermann,Tom W J Huizinga,Rob G H H Nelissen +7 more
TL;DR: Data show that this gene therapy approach targeted at the interface membrane around a loosened hip prosthesis is a feasible treatment option for elderly patients for whom surgical intervention is not appropriate.