J
John F. Marko
Researcher at Northwestern University
Publications - 246
Citations - 16570
John F. Marko is an academic researcher from Northwestern University. The author has contributed to research in topics: DNA & DNA supercoil. The author has an hindex of 64, co-authored 244 publications receiving 14912 citations. Previous affiliations of John F. Marko include University of Illinois at Urbana–Champaign & Massachusetts Institute of Technology.
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Journal ArticleDOI
Entropic elasticity of lambda-phage DNA
Journal ArticleDOI
How do site‐specific DNA‐binding proteins find their targets?
Stephen E. Halford,John F. Marko +1 more
TL;DR: A simplified version of the 'facilitated diffusion' model of Berg, Winter and von Hippel is presented, showing how non-specific DNA-protein interactions may account for accelerated targeting, by permitting the protein to sample many binding sites per DNA encounter.
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Interphase chromosomes undergo constrained diffusional motion in living cells.
Wallace F. Marshall,Aaron F. Straight,John F. Marko,Jason R. Swedlow,Abby F. Dernburg,Andrew S. Belmont,Andrew W. Murray,David A. Agard,John W. Sedat +8 more
TL;DR: It is found that chromatin is free to undergo substantial Brownian motion, but that a given chromatin segment is confined to a subregion of the nucleus, which leads to a model for the regulation of chromosome interactions by nuclear architecture.
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Self-organization of domain structures by DNA-loop-extruding enzymes
Elnaz Alipour,John F. Marko +1 more
TL;DR: A model for generation of defined chromosomal loops is presented, based on molecular machines consisting of two coupled and oppositely directed motile elements which extrude loops from the double helix along which they translocate, while excluding one another sterically.
Journal ArticleDOI
Statistical mechanics of supercoiled DNA
John F. Marko,Eric D. Siggia +1 more
TL;DR: In this paper, the authors constructed an analytic theory for the plectonemic supercoiling of DNA loops using methods from polymer statistical mechanics, and showed that for fractional linking number perturbations ∣σ∣ 0.02, the supercoils are stable, but thermal fluctuations continue to play an important role, competing with bending and twisting elastic energy.