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John H. Postlethwait

Researcher at University of Oregon

Publications -  393
Citations -  42750

John H. Postlethwait is an academic researcher from University of Oregon. The author has contributed to research in topics: Zebrafish & Gene. The author has an hindex of 89, co-authored 379 publications receiving 38634 citations. Previous affiliations of John H. Postlethwait include University of Hawaii at Manoa & University of California, Irvine.

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The zebrafish reference genome sequence and its relationship to the human genome.

Kerstin Howe, +174 more
- 25 Apr 2013 - 
TL;DR: A high-quality sequence assembly of the zebrafish genome is generated, made up of an overlapping set of completely sequenced large-insert clones that were ordered and oriented using a high-resolution high-density meiotic map, providing a clearer understanding of key genomic features such as a unique repeat content, a scarcity of pseudogenes, an enrichment of zebra fish-specific genes on chromosome 4 and chromosomal regions that influence sex determination.
Journal Article

Preservation of duplicate genes by complementary, degenerative mutations.

TL;DR: Cooke et al. as mentioned in this paper proposed a new conceptual framework for understanding the evolution of duplicate genes that may help explain this conundrum, focusing on the regulatory complexity of eukaryotic genes, and showed how complementary degenerative mutations in different regulatory elements of duplicated genes can facilitate the preservation of both duplicates, thereby increasing long-term opportunities for the development of new gene functions.
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Preservation of Duplicate Genes by Complementary, Degenerative Mutations

TL;DR: Focusing on the regulatory complexity of eukaryotic genes, it is shown how complementary degenerative mutations in different regulatory elements of duplicated genes can facilitate the preservation of both duplicates, thereby increasing long-term opportunities for the evolution of new gene functions.
Journal ArticleDOI

Zebrafish hox Clusters and Vertebrate Genome Evolution

TL;DR: Teleosts, the most species-rich group of vertebrates, appear to have more copies of these developmental regulatory genes than do mammals, despite less complexity in the anterior-posterior axis.
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Stacks: Building and Genotyping Loci De Novo From Short-Read Sequences

TL;DR: The algorithms implemented in Stacks are reported and demonstrated to be efficacy by constructing loci from simulated RAD-tags taken from the stickleback reference genome and by recapitulating and improving a genetic map of the zebrafish, Danio rerio.