John Hewetson

TL;DR: A serological correlate of vaccine-induced immunity was identified in the rabbit model of inhalational anthrax and antibody levels to PA at both 6 and 10 weeks were significant predictors of survival.

TL;DR: In this article, the effects of process parameters on structure, surface condition, particle size, core loading and in vitro release properties of the protein-loaded microparticles were studied.

TL;DR: The advantages of microencapsulated RT vaccine to stimulate effective and long-lasting protection by i.n. administration were consistently demonstrated and persistence of antibody response was predictive of efficacy.

TL;DR: Results indicated that successful oral immunization with RT-MS depended on both the dose and the schedule, consisting of three consecutive days of administration in two cycles, 4 weeks apart, and under the conditions of this study, the advantage of the microencapsulated RT vaccine over the aqueous vaccine for effective oral immunizations was well demonstrated.

TL;DR: Intranasal vaccination with two suboptimal doses of deglycosylated chain A ricin stimulated low anti-ricin ELISA IgG and neutralizing antibody responses and the vaccine was only marginally protective against a lethal ricin toxin aerosol challenge, but in the presence of the mucosal adjuvant LTR72, the low antibody response and protection were substantially enhanced.