J
John K. McCormick
Researcher at University of Western Ontario
Publications - 99
Citations - 6298
John K. McCormick is an academic researcher from University of Western Ontario. The author has contributed to research in topics: Superantigen & Toxic shock syndrome. The author has an hindex of 38, co-authored 95 publications receiving 5658 citations. Previous affiliations of John K. McCormick include London Health Sciences Centre & Lawson Health Research Institute.
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Journal ArticleDOI
Potential Uses of Probiotics in Clinical Practice
TL;DR: There is mounting evidence that selected probiotic strains can provide health benefits to their human hosts, and accepted standards and guidelines proposed by the Food and Agriculture Organization of the United Nations and the World Health Organization represent a key step in ensuring that reliable products with suitable, informative health claims become available.
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Toxic Shock Syndrome and Bacterial Superantigens: An Update
TL;DR: It is proposed that there are five distinct groups of bacterial superantigens, which are believed to be responsible for the most severe features of toxic shock syndrome.
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Genome sequence of a serotype M3 strain of group A Streptococcus: Phage-encoded toxins, the high-virulence phenotype, and clone emergence
Stephen B. Beres,Gail L. Sylva,Kent D. Barbian,Benfang Lei,Jessica S. Hoff,Nicole D. Mammarella,Meng Yao Liu,James C. Smoot,Stephen F. Porcella,Larye D. Parkins,David S. Campbell,Todd M. Smith,John K. McCormick,Donald Leung,Patrick M. Schlievert,James M. Musser +15 more
TL;DR: The results show that phage-mediated recombination has played a critical role in the emergence of a new, unusually virulent clone of serotype M3 GAS.
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Identification of a novel two-component regulatory system that acts in global regulation of virulence factors of Staphylococcus aureus.
TL;DR: Results indicate that the putative two-component system encoded by srrAB, SrrA-SrrB, acts in the global regulation of staphylococcal virulence factors, and may repress virulence Factors under low-oxygen conditions.
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A robust scoring system to evaluate sepsis severity in an animal model
Bradly Shrum,Ram Venkatesh Anantha,Stacey X. Xu,Marisa Donnelly,S. M. Mansour Haeryfar,John K. McCormick,Tina Mele +6 more
TL;DR: The MSS reliably predicts disease progression and mortality in an animal model of polymicrobial sepsis, and may be used to assess and compare outcomes among various experimental models of sepsi, and serve as an ethically acceptable alternative to death as an endpoint.