J
John K. Rose
Researcher at Yale University
Publications - 166
Citations - 17906
John K. Rose is an academic researcher from Yale University. The author has contributed to research in topics: Vesicular stomatitis virus & Virus. The author has an hindex of 70, co-authored 166 publications receiving 17405 citations. Previous affiliations of John K. Rose include Yale Cancer Center.
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Journal ArticleDOI
Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface
Deborah A. Brown,John K. Rose +1 more
TL;DR: It is shown that a protein with a glycosylphosphatidyl inositol (GPI) anchor can be recovered from lysates of epithelial cells in a low density, detergent-insoluble form, supporting the model proposed by Simons and colleagues for sorting of certain membrane proteins to the apical surface after intracellular association with glycosphingolipids.
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Recombinant vesicular stomatitis viruses from DNA
TL;DR: The ability to generate VSV from DNA opens numerous possibilities for the genetic analysis of VSV replication and may be possible to genetically engineer recombinant VSVs displaying foreign antigens, which could be useful as vaccines conferring protection against other viruses.
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Folding and assembly of viral membrane proteins.
TL;DR: It is now clear that folding in the ER is a dynamic, energy-driven process involving a host of cellular folding enzymes and molecular chaperones, and whether quality control mechanisms play significant roles in regulating protein transport in other organelles represents an interesting area of research.
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An Effective AIDS Vaccine Based on Live Attenuated Vesicular Stomatitis Virus Recombinants
Nina F. Rose,Preston A. Marx,Preston A. Marx,Amara Luckay,Douglas F. Nixon,Walter J. Moretto,Sean M. Donahoe,David C. Montefiori,Anjeanette Roberts,Linda Buonocore,John K. Rose +10 more
TL;DR: An AIDS vaccine based on attenuated VSV vectors expressing env and gag genes and tested it in rhesus monkeys, finding protection from AIDS was highly significant.
Journal Article
A new cationic liposome reagent mediating nearly quantitative transfection of animal cells.
TL;DR: Liposomes containing DDAB are an inexpensive, highly efficient and reproducible alternative for the transfection of animal cells and are well suited for use with the vaccinia virus/T7 expression system.