John Katsaras

TL;DR: The structural parameters of fluid phase bilayers composed of phosphatidylcholines with fully saturated, mixed, and branched fatty acid chains, at several temperatures, have been determined by simultaneously analyzing small-angle neutron and X-ray scattering data to assess the effect of temperature and hydrocarbon chain composition on bilayer structure.

TL;DR: An improved method for determining lipid areas helps to reconcile long-standing differences in the values of lipid areas obtained from stand-alone x-ray and neutron scattering experiments and poses new challenges for molecular dynamics simulations.

TL;DR: The temperature dependence of bilayer parameters obtained using the one-dimensional scattering density profile model - which was derived from molecular dynamics simulations - including the area per lipid, the overall bilayer thickness, as well as other intrabilayer parameters (e.g., hydrocarbon thickness).

TL;DR: The simulations allow us to analyze the behavior of cholesterol in detail and show that the interaction of cholesterol with the PUFA chains of DAPC leads to a fast flip-flop rate for the sterol and an increased preference ofThe sterol for the unusual location embedded between the monolayer leaflets.

TL;DR: Some of the latest model membrane results are reported, and the neutron and X-ray techniques that were used to obtain them are reported.