J
John Lamb
Researcher at Science for Life Laboratory
Publications - 36
Citations - 3057
John Lamb is an academic researcher from Science for Life Laboratory. The author has contributed to research in topics: Blood proteins & Transplantation. The author has an hindex of 17, co-authored 35 publications receiving 2318 citations. Previous affiliations of John Lamb include Genomics Institute of the Novartis Research Foundation & Stockholm University.
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Journal ArticleDOI
Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease
Bin Zhang,Chris Gaiteri,Liviu-Gabriel Bodea,Zhi Wang,Joshua J McElwee,Alexei A. Podtelezhnikov,Chunsheng Zhang,Tao Xie,Linh M. Tran,Radu Dobrin,Eugene M. Fluder,Bruce E. Clurman,Stacey Melquist,Manikandan Narayanan,Christine Suver,Hardik Shah,Milind Mahajan,Tammy Gillis,Jayalakshmi S. Mysore,Marcy E. MacDonald,John Lamb,David A. Bennett,Cliona Molony,David J. Stone,Vilmundur Gudnason,Amanda J. Myers,Eric E. Schadt,Harald Neumann,Jun Zhu,Valur Emilsson +29 more
TL;DR: The causal network structure is a useful predictor of response to gene perturbations and presents a framework to test models of disease mechanisms underlying LOAD.
Journal ArticleDOI
Co-regulatory networks of human serum proteins link genetics to disease
Valur Emilsson,Marjan Ilkov,John Lamb,Nancy Finkel,Elias F. Gudmundsson,Rebecca Pitts,Heather Hoover,Valborg Gudmundsdottir,Shane R. Horman,Thor Aspelund,Le Shu,Vladimir Trifonov,Sigurdur Sigurdsson,Andrei Manolescu,Jun Zhu,Orn Olafsson,Johanna Jakobsdottir,Scott A. Lesley,Jeremy To,Jia Zhang,Tamara B. Harris,Lenore J. Launer,Bin Zhang,Gudny Eiriksdottir,Xia Yang,Anthony P. Orth,Lori L. Jennings,Vilmundur Gudnason +27 more
TL;DR: A deep proteome analysis of human serum reveals the relationship between disease and genetics and revealed co-regulated groups of circulating proteins that incorporated regulatory control between tissues and demonstrated close relationships to past, current, and future disease states.
Journal ArticleDOI
In vivo discovery of immunotherapy targets in the tumour microenvironment
Penghui Zhou,Donald R. Shaffer,Diana A. Alvarez Arias,Yukoh Nakazaki,Wouter Pos,Alexis J. Torres,Viviana Cremasco,Stephanie K. Dougan,Glenn S. Cowley,Kutlu G. Elpek,Jennifer Brogdon,John Lamb,Shannon J. Turley,Hidde L. Ploegh,David E. Root,J. Christopher Love,Glenn Dranoff,Nir Hacohen,Harvey Cantor,Kai W. Wucherpfennig +19 more
TL;DR: Key regulators of immune function can be discovered in relevant tissue microenvironments through an in vivo pooled short hairpin RNA (shRNA) screen in which shRNAs targeting negative regulators became highly enriched in murine tumours by releasing a block on T-cell proliferation upon tumour antigen recognition.
Journal ArticleDOI
Inhibition of DYRK1A and GSK3B induces human β-cell proliferation.
Weijun Shen,Brandon Taylor,Qihui Jin,Van Nguyen-Tran,Shelly Meeusen,You-Qing Zhang,Anwesh Kamireddy,Austin De Swafford,Andrew F. Powers,John P Walker,John Lamb,Badry Bursalaya,Michael DiDonato,George Harb,Minhua Qiu,Christophe M. Filippi,Lisa Deaton,Carolina N. Turk,Wilma L. Suarez-Pinzon,Yahu Liu,Xueshi Hao,Tingting Mo,Shanshan Yan,Jing-Jing Li,Ann E. Herman,Bernhard J. Hering,Tao Wu,H. Martin Seidel,Peter McNamara,Richard Glynne,Bryan Laffitte +30 more
TL;DR: The feasibility of treating diabetes with an oral therapy to restore β-cell mass is supported, a tractable pathway for future drug discovery efforts is highlighted, and Dyrk1a is highlighted as the key molecular target.
Journal ArticleDOI
DisProt: intrinsic protein disorder annotation in 2020.
András Hatos,Borbála Hajdu-Soltész,Alexander Miguel Monzon,Nicolas Palopoli,Lucía Álvarez,Burcu Aykac-Fas,Claudio Bassot,Guillermo Ignacio Benitez,Martina Bevilacqua,Anastasia Chasapi,Lucía B. Chemes,Norman E. Davey,Radoslav Davidovic,A. Keith Dunker,Arne Elofsson,Julien Gobeill,Nicolás Sebastián González Foutel,Govindarajan Sudha,Mainak Guharoy,Mainak Guharoy,Tamas L. Horvath,Valentin Iglesias,Andrey V. Kajava,Orsolya P Kovacs,John Lamb,Matteo Lambrughi,Tamas Lazar,Tamas Lazar,Jeremy Y Leclercq,Emanuela Leonardi,Sandra Macedo-Ribeiro,Mauricio Macossay-Castillo,Mauricio Macossay-Castillo,Emiliano Maiani,José A. Manso,Cristina Marino-Buslje,Elizabeth Martínez-Pérez,Bálint Mészáros,Ivan Mičetić,Giovanni Minervini,Nikoletta Murvai,Marco Necci,Christos A. Ouzounis,Mátyás Pajkos,Lisanna Paladin,Rita Pancsa,Elena Papaleo,Gustavo Parisi,Emilie Pasche,Pedro Pereira,Vasilis J. Promponas,Jordi Pujols,Federica Quaglia,Patrick Ruch,Marco Salvatore,Eva Schad,Beáta Szabó,Tamás Szaniszló,Stella Tamana,Agnes Tantos,Nevena Veljkovic,Salvador Ventura,Wim F. Vranken,Wim F. Vranken,Zsuzsanna Dosztányi,Peter Tompa,Peter Tompa,Peter Tompa,Silvio C. E. Tosatto,Damiano Piovesan +69 more
TL;DR: Recent developments with DisProt (version 8), including the doubling of protein entries, a new disorder ontology, improvements of the annotation format and a completely new website are reported.