John M. Buatti

TL;DR: An overview of 3D Slicer is presented as a platform for prototyping, development and evaluation of image analysis tools for clinical research applications and the utility of the platform in the scope of QIN is illustrated.

TL;DR: The RS in conjunction with WBRT for single brain metastasis can produce substantial functional survival, especially in patients with good performance status and without extracranial metastasis, which strongly suggest that a randomized trial to compare RS with surgery is warranted.

TL;DR: Omission of up-front WBRT does not seem to compromise length of survival in patients treated with RS for newly diagnosed brain metastases, and there was no survival difference comparing RS alone initially to RS + up- front W BRT.

TL;DR: It is shown that alterations in cancer cell mitochondrial oxidative metabolism resulting in increased levels of O2⋅- and H2O2 are capable of disrupting intracellular iron metabolism, thereby selectively sensitizing non-small-cell lung cancer and glioblastoma cells to ascorbate through pro-oxidant chemistry involving redox-active labile iron and H 2O2.

TL;DR: Benign meningiomas are well managed by TE or SE+RT and atypical pathologic features predict a poorer outcome, suggesting possible benefit from more aggressive treatment.