J
John M. Parant
Researcher at University of Alabama at Birmingham
Publications - 34
Citations - 5301
John M. Parant is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Mutant & Zebrafish. The author has an hindex of 17, co-authored 30 publications receiving 4824 citations. Previous affiliations of John M. Parant include University of Utah & University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
The Tol2kit: a multisite gateway-based construction kit for Tol2 transposon transgenesis constructs.
Kristen M. Kwan,Esther Fujimoto,Clemens Grabher,Benjamin D. Mangum,Melissa Hardy,Douglas Simon Campbell,John M. Parant,H. Joseph Yost,John P. Kanki,Chi Bin Chien +9 more
TL;DR: The Tol2kit greatly facilitates zebrafish transgenesis, simplifies the sharing of clones, and enables large‐scale projects testing the functions of libraries of regulatory or coding sequences.
Journal ArticleDOI
Gain of Function of a p53 Hot Spot Mutation in a Mouse Model of Li-Fraumeni Syndrome
Gene A. Lang,Tomoo Iwakuma,Young Ah Suh,Geng Liu,V. Ashutosh Rao,John M. Parant,Yasmine A. Valentin-Vega,Tamara Terzian,Lisa C. Caldwell,Louise C. Strong,Adel K. El-Naggar,Guillermina Lozano +11 more
TL;DR: In vivo validation for the gain-of-function properties of certain p53 missense mutations are provided and a mechanistic basis for these phenotypes is suggested.
Journal ArticleDOI
Pirh2, a p53-Induced Ubiquitin-Protein Ligase, Promotes p53 Degradation
Roger P. Leng,Yunping Lin,Weili Ma,Hong Wu,Bénédicte Lemmers,Bénédicte Lemmers,Stephen Chung,John M. Parant,Guillermina Lozano,Razqallah Hakem,Razqallah Hakem,Samuel Benchimol +11 more
TL;DR: Pirh2, a gene regulated by p53 that encodes a RING-H2 domain-containing protein with intrinsic ubiquitin-protein ligase activity, is described and it is proposed that Pirh2 is involved in the negative regulation of p53 function through physical interaction and ubiquit in-mediated proteolysis.
Journal ArticleDOI
Rescue of embryonic lethality in Mdm4 -null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53
John M. Parant,Arturo Chavez-Reyes,Arturo Chavez-Reyes,Natalie A. Little,Wen Yan,Valerie Reinke,Aart G. Jochemsen,Guillermina Lozano +7 more
TL;DR: MDM2 and MDM4 are nonoverlapping critical regulators of p53 in vivo, which define a new pathway of p 53 regulation and raise the possibility that increasedMDM4 levels and the resulting inactivation of p52 contribute to the development of human tumors.
Journal ArticleDOI
Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice.
Geng Liu,John M. Parant,Gene Lang,Patty Chau,Arturo Chavez-Reyes,Adel K. El-Naggar,Asha S. Multani,Sandy Chang,Guillermina Lozano +8 more
TL;DR: The ability of mutant p53-R172P to induce a partial cell cycle arrest and retain chromosome stability are crucial for suppression of early onset tumorigenesis.