John M. Tarbell

TL;DR: The mechanical and biochemical properties of the EGL and the latest studies on the interactions of this layer with red and white blood cells are examined, including its deformation owing to fluid shear stress, its penetration by leukocyte microvilli, and its restorative response after the passage of a white cell in a tightly fitting capillary.

TL;DR: These data show that diabetes selectively reduces retinal occludin protein expression and increases BRB permeability, and suggest that the elevated VEGF in the vitreous of patients with diabetic retinopathy increases vascular permeability by downregulating occlUDin content.

TL;DR: These experiments demonstrate that a heparan sulfate component of the EC glycocalyx participates in mechanosensing that mediates NO production in response to shear stress.

TL;DR: The evidence in support of the surface glycocalyx acting as a mechanotransducer of shear stress by ECs is considered and the mechanisms by which these forces are transduced into biomolecular responses of the cells are considered.

TL;DR: The results may be interpreted in terms of a glypican-caveolae-eNOS mechanism for shear-induced NO transduction, with PGI(2) being transduced in basal adhesion plaques that sense the same reaction stress whether the glycocalyx is intact or not.