J
John M. Whitelock
Researcher at University of New South Wales
Publications - 149
Citations - 6964
John M. Whitelock is an academic researcher from University of New South Wales. The author has contributed to research in topics: Perlecan & Heparan sulfate. The author has an hindex of 42, co-authored 140 publications receiving 6124 citations. Previous affiliations of John M. Whitelock include Thomas Jefferson University & University of Sydney.
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The Degradation of Human Endothelial Cell-derived Perlecan and Release of Bound Basic Fibroblast Growth Factor by Stromelysin, Collagenase, Plasmin, and Heparanases
TL;DR: These findings provide direct evidence that bFGF binds to heparan sulfate sequences attached to domain I and support the hypothesis that perlecan represents a major storage site for this growth factor in the blood vessel wall and may modulate the bioavailability of the growth factor.
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Heparan sulfate: a complex polymer charged with biological activity.
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Diverse cell signaling events modulated by perlecan.
TL;DR: The pro-angiogenic capacities of perlecan that involve proliferative and migratory signals in response to bound growth factors will be explored, as well as the anti-angIogenic signals resulting from interactions between the C-terminal domain known as endorepellin and integrins that control adhesion of cells to the extracellular matrix.
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Antisense targeting of perlecan blocks tumor growth and angiogenesis in vivo.
Bela Sharma,Michael H. Handler,Inge Eichstetter,John M. Whitelock,Matthew A. Nugent,Renato V. Iozzo +5 more
TL;DR: Perlecan is a potent inducer of tumor growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve cancer treatment.
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Oxidative damage to extracellular matrix and its role in human pathologies.
TL;DR: The potential sources of oxidative matrix damage, the changes that occur in matrix structure, and how this may affect cellular behavior are reviewed and the role of such damage in the development and progression of inflammatory diseases is discussed.