John Muscedere

TL;DR: These guidelines are intended for use by healthcare professionals who care for patients at risk for hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP), including specialists in infectious diseases, pulmonary diseases, critical care, and surgeons, anesthesiologists, hospitalists, and any clinicians and healthcare providers caring for hospitalized patients with nosocomial pneumonia.

TL;DR: End-expiratory lung volume is an important determinant of the degree and site of lung injury during positive-pressure ventilation as ventilation occurs from below to above the infection point (Pinf) as determined from the inspiratory pressure-volume curve.

TL;DR: Early provision of glutamine or antioxidants did not improve clinical outcomes, and glutamine was associated with an increase in mortality among critically ill patients with multiorgan failure.

TL;DR: The methods used to create the VAP Prevention Guideline Panel, an evidence-based clinical practice guideline for the prevention of VAP, and the recommendations generated are described.

TL;DR: Frailty is common in patients admitted to ICU and is associated with worsened outcomes, and Identification of this previously unrecognized and vulnerable ICU population should act as the impetus for investigating and implementing appropriate care plans for critically ill frail patients.