Showing papers by "John Q. Trojanowski published in 1980"
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TL;DR: Criteria were developed for establishing the nerve sheath origin and malignancy of a given neoplasm which allowed a secure diagnosis of malignant nerve she Heath tumor to be made in 11 of the 24 cases, and 7 cases were of uncertain histogenesis.
Abstract: A clinicopathologic study of malignant nerve sheath tumors diagnosed between 1962 and 1979 at the Massachusetts General Hospital was undertaken. During this 17-year period, 24 patients with such a neoplasm were seen while 607 patients were treated for schwannoma or neurofibroma. Criteria were developed for establishing the nerve sheath origin and malignancy of a given neoplasm which allowed a secure diagnosis of malignant nerve sheath tumor to be made in 11 of the 24 cases. In 7 of the remaining cases, the malignant tumors were of uncertain histogenesis and in 6 cases, a new diagnosis was made. The malignant tumors constituted 2% of all neoplasms of the nerve sheath origin diagnosed during this period. An attempt was made to grade these neoplasms, but clinical and histologic parameters were only approximately predictive of their behavior. The treatment and survival or the 11 patients with malignant nerve sheath tumors and the 7 with malignant neoplasms of uncertain histogenesis are detailed and compared. In the former group, 4 patients died within four and a half years and there were eight recurrences in 4 patients. In the latter group, 4 died within three and a half years and there were five recurrences in 3 patients.
93 citations
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TL;DR: Two cases are described in which therapeutic transcatheter Gelfoam embolization was complicated by fatal hepatic infarction in one patient and splenicinfarction with abscess formation in another patient.
Abstract: Two cases are described in which therapeutic transcatheter Gelfoam embolization was complicated by fatal hepatic infarction in one patient and splenic infarction with abscess formation in another patient. These are unusual complications of this widely used therapeutic technique. The probable pathophysiology of these complications is discussed and suggestions for managing and avoiding them are made.
53 citations
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TL;DR: A 58-year-old man developed a selective supranuclear paralysis of downgaze, which was repeatedly documented until it completely resolved after 6 weeks, with a bilaterally symmetric old infarct in the mesodiencephalic region.
Abstract: A 58-year-old man developed a selective supranuclear paralysis of downgaze, which was repeatedly documented until it completely resolved after 6 weeks. At autopsy, there was a bilaterally symmetric old infarct in the mesodiencephalic region. In common with four previous similar reports, the lesion involved structures bordering the dorsomedial aspect of the red nucleus. This same region has been implicated in the control of vertical eye movements in recent neuroanatomic and physiologic experiments in nonhuman primates.
51 citations
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TL;DR: This case provides evidence that cerebral dominance for speech and handedness in dextrals may be dissociated and suggests that lesions of the precentral gyrus are of major importance in producing Broca aphasia.
Abstract: Article abetract—Severe Broca aphasia and left hemiplegia without right limb apraxia occurred suddenly in a right-handed man with no personal or family history of left-handedness. Postmortem examination showed infarction of the right hemisphere, limited almost entirely to the precentral gyrus. In this patient, cerebral dominance for speech lay in the right hemisphere, but dominance for limb praxis lay in the left. This case provides evidence that cerebral dominance for speech and handedness in dextrals may be dissociated. It also suggests that lesions of the precentral gyrus are of major importance in producing Broca aphasia.
43 citations