J
John Q. Trojanowski
Researcher at University of Pennsylvania
Publications - 1538
Citations - 245534
John Q. Trojanowski is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Dementia & Alzheimer's disease. The author has an hindex of 226, co-authored 1467 publications receiving 213948 citations. Previous affiliations of John Q. Trojanowski include Vanderbilt University & University of California, San Francisco.
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Cerebral ischemia and CNS transplantation: differential effects of grafted fetal rat striatal cells and human neurons derived from a clonal cell line.
TL;DR: It is reported here that ischemia-induced behavioral dysfunctions were ameliorated by the neural grafts as early as 1 month post-transplantation, and the logistical and ethical concerns about the use of fetal striatal cells for transplantation therapy can be eliminated by exploiting cell line-derived human neurons as alternative graft sources.
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TDP-43 skeins show properties of amyloid in a subset of ALS cases.
John L. Robinson,Felix Geser,Felix Geser,Anna Stieber,Mfon Umoh,Linda K. Kwong,Vivianna M. Van Deerlin,Virginia M.-Y. Lee,John Q. Trojanowski +8 more
TL;DR: The demonstration that pathological TDP-43 can be amyloidogenic in situ suggests the following conclusions: (1) the conformational changes associated with T DP-43 aggregation are more complex than previously thought; (2) Thioflavin-S positive SLI may be composed primarily of filamentous ultrastructures.
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Transmission of tauopathy strains is independent of their isoform composition
Zhuohao He,Zhuohao He,Jennifer D. McBride,Hong Xu,Lakshmi Changolkar,Soo-Jung Kim,Bin Zhang,Sneha Narasimhan,Garrett S. Gibbons,Jing L. Guo,Michael Kozak,Gerard D. Schellenberg,John Q. Trojanowski,Virginia M.-Y. Lee +13 more
TL;DR: A new transgenic mouse line is generated expressing 6 human tau isoforms with equal 3R and 4R ratios, recapitulate distinct human t Tau strains in mouse brains with similar isoform compositions and cell type specificities, and further show the strain transmission pattern is independent of its isoform composition.
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Diagnostic accuracy of CSF Ab42 and florbetapir PET for Alzheimer's disease.
Niklas Mattsson,Niklas Mattsson,Niklas Mattsson,Philip S. Insel,Susan M. Landau,William J. Jagust,Michael C. Donohue,Leslie M. Shaw,John Q. Trojanowski,Henrik Zetterberg,Henrik Zetterberg,Kaj Blennow,Michael W. Weiner,Michael W. Weiner +13 more
TL;DR: Reduced cerebrospinal fluid β‐amyloid42 (Aβ42) and increased florbetapir positron emission tomography (PET) uptake reflects brain Aβ accumulation and is correlated with each other and altered in Alzheimer's disease (AD).
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Anxiety is related to Alzheimer cerebrospinal fluid markers in subjects with mild cognitive impairment
Inez H.G.B. Ramakers,Frans R.J. Verhey,P. Scheltens,Harald Hampel,H. Soininen,Pauline Aalten,M.G.M. Olde Rikkert,Marcel M. Verbeek,Luiza Spiru,Kaj Blennow,John Q. Trojanowski,Les Shaw,Pieter Jelle Visser +12 more
TL;DR: In subjects with MCI, symptoms of anxiety, agitation and irritability may reflect underlying AD pathology, whereas symptoms of depression and apathy do not.