John Q. Trojanowski

TL;DR: The detection of Aβ11-42 in young DS brain suggests an early role for this N-terminally truncated Aβ peptide in the pathogenesis of SPs in AD and DS brains.

TL;DR: The findings suggest that both biomarkers measure different aspects of AD Aβ pathology, and 4 different approaches in 2 different platforms converge on similar pathological Aβ cutoff levels; and different pipelines to process PET scans showed correlated but not identical results.

TL;DR: This article examined a series of markers including a cell proliferation marker, neurofilament proteins, and glial fibrillary acidic protein (GFAP) in teratomas at 5, 6, 7, 9, and 12 weeks after rhesus ES cell transplantation into muscles of immunodeficient mice.

TL;DR: It is implied that reductions in non-AD pathologies including CVD contribute to cognitive resilience in the oldest-old.

TL;DR: Low levels of the most heavily phosphorylated isoforms of mouse NFH were reduced in the brains of these transgenic mice, and electron microscopic studies showed a higher packing density of NFs in large-diameter CNS axons of transgenic versus wild-type mice, implying that NFM may play a dominant role in the in vivo regulation of the levels of NFL protein, the stoichiometry of NF subunits, and the phosphorylation state of NFH.