J
John Q. Trojanowski
Researcher at University of Pennsylvania
Publications - 1538
Citations - 245534
John Q. Trojanowski is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Dementia & Alzheimer's disease. The author has an hindex of 226, co-authored 1467 publications receiving 213948 citations. Previous affiliations of John Q. Trojanowski include Vanderbilt University & University of California, San Francisco.
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Early fetal acquisition of the chromaffin and neuronal immunophenotype by human adrenal medullary cells. An immunohistological study using monoclonal antibodies to chromogranin A, synaptophysin, tyrosine hydroxylase, and neuronal cytoskeletal proteins.
TL;DR: Observations indicate that chromaffin and ganglion cells establish their immunophenotype early in embryogenesis, and suggest that "large" and "small" cells are progenitors of the chromAffin and the ganglions cells, respectively, of the mature adrenal medulla.
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Low Plasma Leptin in Cognitively Impaired ADNI Subjects: Gender Differences and Diagnostic and Therapeutic Potential
Jane M. Johnston,William T. Hu,David W. Fardo,Steven J. Greco,George Perry,Thomas J. Montine,John Q. Trojanowski,Leslie M. Shaw,J. Wesson Ashford,Nikolaos Tezapsidis +9 more
TL;DR: Analysis of data derived from the ADNI program showed plasma leptin levels in individuals with Mild Cognitive Impairment (MCI) or Alzheimer's disease (AD) to be lower than those of subjects with normal cognition (NC), suggesting that plasma leptin deficiency provides an indication of potential CNS leptin deficiency.
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The older rabbit as an animal model: Implications for Alzheimer's disease
TL;DR: The results of the search for Alzheimer-like neuropathology in aged rabbit brains are reported to highlight similarities in the brain mechanisms for EBCC between rabbits and humans and, hence, the utility of studies of E BCC in rabbits as a model system for testing cognition-enhancing drugs.
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Phosphorylation of Neuronal Cytoskeletal Proteins in Alzheimer's Disease and Lewy Body Dementiasa
TL;DR: Heterogeneity in the etiology of Alzheimer’s disease could make it necessary to “solve” the riddle of AD multiple times in order to prevent or block the progression of each variant of this late life dementia.
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Patterns of striatal degeneration in frontotemporal dementia.
Cathra Halabi,Anasheh Halabi,David Dean,Pei Ning Wang,Adam L. Boxer,John Q. Trojanowski,Stephen J. DeArmond,Bruce L. Miller,Joel H. Kramer,William W. Seeley +9 more
TL;DR: It is demonstrated that ventral striatum degeneration is a prominent shared feature in behavioral variant frontotemporal dementia and semantic dementia and may contribute to the social-emotional deficits common to both disorders.