J
John Q. Trojanowski
Researcher at University of Pennsylvania
Publications - 1538
Citations - 245534
John Q. Trojanowski is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Dementia & Alzheimer's disease. The author has an hindex of 226, co-authored 1467 publications receiving 213948 citations. Previous affiliations of John Q. Trojanowski include Vanderbilt University & University of California, San Francisco.
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Journal Article
Nerve growth factor receptor expression in peripheral and central neuroectodermal tumors, other pediatric brain tumors, and during development of the adrenal gland.
David L. Baker,Willemina M. Molenaar,John Q. Trojanowski,Audrey E. Evans,Alonzo H. Ross,Lucy B. Rorke,Roger J. Packer,Virginia M.-Y. Lee,David E Pleasure +8 more
TL;DR: In most CNS PNETs, NGFR was restricted to scattered single or small groups of cells, but two tumors with astroglial differentiation showed much more extensive immunoreactivity, and most astrocytomas and all ependymomas were intensely NGFR positive.
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A novel modification of the avidin-biotin complex method for immunohistochemical studies of transgenic mice with murine monoclonal antibodies.
TL;DR: This novel, indirect immunohistochemical method can be exploited to study normal and diseased mouse tissues using a variety of murine MAb and the labeling of irrelevant, endogenous mouse immunoglobulins was reduced substantially.
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Genetic variation in the brain derived neurotrophic factor gene in Alzheimer's disease.
Sara M. Bodner,Wade H. Berrettini,Vivianna M. Van Deerlin,David A. Bennett,Robert S. Wilson,John Q. Trojanowski,Steven E. Arnold +6 more
TL;DR: A case control study of three BDNF SNPs in 250 neuropathologically confirmed cases of AD and 194 unrelated controls did not find a significant association between the three BD NF SNPs studied and AD when evaluated individually or with haplotype analysis.
Alzheimer’s disease biomarkers: from concept to clinical utility
Hugo Vanderstichele,G. De Meyer,F. Shapiro,Sebastiaan Engelborghs,P.P. De Deyn,Leslie M. Shaw,John Q. Trojanowski +6 more
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BACE1 activity is modulated by cell-associated sphingosine-1-phosphate
Taisuke Tomita,Nobumasa Takasugi,Tomoki Sasaki,Satoko Osawa,Satoshi Yokoshima,Tohru Fukuyama,Virginia M.-Y. Lee,John Q. Trojanowski,Takeshi Iwatsubo +8 more
TL;DR: By understanding how the PS1 double mutant F411Y/S438P can form active gsecretase complexes in the absence of nicastrin, the authors will get more insight into nicastin’s function within the complex.