J
John Q. Trojanowski
Researcher at University of Pennsylvania
Publications - 1538
Citations - 245534
John Q. Trojanowski is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Dementia & Alzheimer's disease. The author has an hindex of 226, co-authored 1467 publications receiving 213948 citations. Previous affiliations of John Q. Trojanowski include Vanderbilt University & University of California, San Francisco.
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Journal ArticleDOI
Progressive Atrophy and Neuron Death for One Year Following Brain Trauma in the Rat
Douglas H. Smith,Xiao-Han Chen,Jean E.S. Pierce,John A. Wolf,John Q. Trojanowski,David I. Graham,Tracy K. McIntosh +6 more
TL;DR: The results suggest that a chronically progressive degenerative process may be initiated by brain trauma and there is a temporally broad window within which to introduce novel therapeutic strategies designed to ameliorate the short and long-term consequences of brain trauma.
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Axon pathology in Parkinson's disease and Lewy body dementia hippocampus contains alpha-, beta-, and gamma-synuclein.
TL;DR: This work shows that in PD and DLB, but not normal brains, antibodies to alphaS and betaS reveal novel presynaptic axon terminal pathology in the hippocampus, hilar, and CA2/3 regions, whereas antibodies to gammaS detect previously unrecognized axonal spheroid-like lesions in the hippocampal dentate molecular layer.
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CSF biomarkers of Alzheimer's disease concord with amyloid-β PET and predict clinical progression: A study of fully automated immunoassays in BioFINDER and ADNI cohorts
Oskar Hansson,John Seibyl,Erik Stomrud,Henrik Zetterberg,John Q. Trojanowski,Tobias Bittner,Valeria Lifke,Veronika Corradini,Udo Eichenlaub,Richard Batrla,Katharina Buck,Katharina Zink,Christina Rabe,Kaj Blennow,Kaj Blennow,Leslie M. Shaw,Alzheimer’s Disease Neuroimaging Initiative +16 more
TL;DR: This study studied whether fully automated Elecsys cerebrospinal fluid immunoassay results were concordant with positron emission tomography (PET) and predicted clinical progression, even with cutoffs established in an independent cohort.
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Dopamine neurons implanted into people with Parkinson’s disease survive without pathology for 14 years
Ivar Mendez,Angel Viñuela,Arnar Astradsson,Karim Mukhida,Penelope J. Hallett,Harold A. Robertson,Travis S. Tierney,Renn Holness,Alain Dagher,John Q. Trojanowski,Ole Isacson +10 more
TL;DR: Postmortem analysis of five subjects with Parkinson's disease 9–14 years after transplantation of fetal midbrain cell suspensions revealed surviving grafts that included dopamine and serotonin neurons without pathology.
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Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies
Chao Peng,Ronald J. Gathagan,Dustin J. Covell,Coraima Medellin,Anna Stieber,John L. Robinson,Bin Zhang,Rose M. Pitkin,Modupe F. Olufemi,Kelvin C. Luk,John Q. Trojanowski,Virginia M.-Y. Lee +11 more
TL;DR: It is found that oligodendrocytes but not neurons transform misfolded α-Syn into a GCI-like strain, highlighting the fact that distinct α- synuclein strains are generated by different intracellular milieus, andGCI-α-Syn maintains its high seeding activity when propagated in neurons.