J
John Q. Trojanowski
Researcher at University of Pennsylvania
Publications - 1538
Citations - 245534
John Q. Trojanowski is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Dementia & Alzheimer's disease. The author has an hindex of 226, co-authored 1467 publications receiving 213948 citations. Previous affiliations of John Q. Trojanowski include Vanderbilt University & University of California, San Francisco.
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Journal ArticleDOI
Clinicopathological correlations in corticobasal degeneration
Suzee E. Lee,Gil D. Rabinovici,Mary Catherine Mayo,Stephen M. Wilson,Stephen M. Wilson,William W. Seeley,Stephen J. DeArmond,Eric J. Huang,John Q. Trojanowski,Matthew E. Growdon,Jung Y. Jang,Manu Sidhu,Tricia See,Anna Karydas,Maria Luisa Gorno-Tempini,Adam L. Boxer,Michael W. Weiner,Michael D. Geschwind,Katherine P. Rankin,Bruce L. Miller +19 more
TL;DR: To characterize cognitive and behavioral features, physical findings, and brain atrophy patterns in pathology‐proven corticobasal degeneration (CBD) and corticOBasal syndrome (CBS) with known histopathology.
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Association of cerebrospinal fluid neurofilament light concentration with Alzheimer disease progression
Henrik Zetterberg,Henrik Zetterberg,Tobias Skillbäck,Niklas Mattsson,John Q. Trojanowski,Erik Portelius,Leslie M. Shaw,Michael W. Weiner,Kaj Blennow +8 more
TL;DR: Cerebrospinal fluid NFL concentration is increased by the early clinical stage of AD and is associated with cognitive deterioration and structural brain changes over time, which corroborates the contention that degeneration of large-caliber axons is an important feature of AD neurodegeneration.
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Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein
Alphonse Probst,Juergen Gotz,Karl-Heinz Wiederhold,Markus Tolnay,Claudia Mistl,Anne-Lise Jaton,Ming Hong,Takeshi Ishihara,Virginia M.-Y. Lee,John Q. Trojanowski,Ross Jakes,R.A. Crowther,Maria Grazia Spillantini,Kurt Bürki,Michel Goedert +14 more
TL;DR: It is demonstrated that overexpression of human four-repeat tau leads to a central and peripheral axonopathy that results in nerve cell dysfunction and amyotrophy.
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Transplantation of cryopreserved human embryonal carcinoma-derived neurons (NT2N cells) promotes functional recovery in ischemic rats
TL;DR: The long-term viability of cryopreserved NT2N cell Xenografts in vivo and their sustained effectiveness in promoting behavioral recovery suggest potential utilization of xenografting and Cryopreservation as useful protocols for establishing clone cell lines as graft source in neural transplantation therapies for central nervous system disorders.
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Association of Cerebrospinal Fluid β-Amyloid 1-42, T-tau, P-tau181, and α-Synuclein Levels With Clinical Features of Drug-Naive Patients With Early Parkinson Disease
Ju-Hee Kang,Ju-Hee Kang,David J. Irwin,Alice Chen-Plotkin,Andrew Siderowf,Chelsea Caspell,Christopher S. Coffey,Teresa Waligorska,Peggy Taylor,Sarah Pan,Mark Frasier,Kenneth Marek,Karl Kieburtz,Danna Jennings,Tanya Simuni,Caroline M. Tanner,Andrew B. Singleton,Arthur W. Toga,Sohini Chowdhury,Brit Mollenhauer,John Q. Trojanowski,Leslie M. Shaw,Shirley Lasch,Emily Flagg,Werner Poewe,Todd Sherer,Claire Meunier,Alice Rudolph,Cindy Casaceli,John Seibyl,Susan Mendick,Norbert Schuff,Liz Uribe,Jon W. Yankey,Karen Crawford,Alison Scutti,Paola Casalin,Giulia Malferrari,Keith A. Hawkins,David W. Russell,Laura Leary,Stewart A. Factor,Barbara Sommerfeld,Penelope Hogarth,Emily Pighetti,Karen Williams,David Standaert,Stephanie Guthrie,Robert A. Hauser,Joseph Jankovic,Christine Hunter,Matthew B. Stern,Abigail Darin,James B. Leverenz,Marne Baca,Sam Frank,Cathi-Ann Thomas,Irene Richard,Cheryl Deeley,Linda Rees,Fabienne Sprenger,Wolfgang Oertel,Diana Willeke,Holly A. Shill,Hubert H. Fernandez,Jennifer Mule,Daniela Berg,Katharina Gauss,Douglas Galasko,Deborah Fontaine,Zoltan Mari,Arita McCoy,David Brooks,Bina Shah,Paolo Barone,Stuart Isaacson,Angela James,Alberto J. Espay,Kristy J. Espay,Dominic B. Rowe,Madelaine Ranola +80 more
TL;DR: It is found that measures of CSF Aβ1-42, T-t Tau, P-tau181, and α-synuclein have prognostic and diagnostic potential in early-stage PD.