J
John Q. Trojanowski
Researcher at University of Pennsylvania
Publications - 1538
Citations - 245534
John Q. Trojanowski is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Dementia & Alzheimer's disease. The author has an hindex of 226, co-authored 1467 publications receiving 213948 citations. Previous affiliations of John Q. Trojanowski include Vanderbilt University & University of California, San Francisco.
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PP2A mRNA expression is quantitatively decreased in Alzheimer's disease hippocampus.
TL;DR: This study delineates the distribution of critical PP2A mRNAs and reveals a neuron- and subunit-specific reduction inPP2A catalytic and regulatory mRNA in AD hippocampus, which could result in decreased protein expression and phosphatase activity, leading to the hyperphosphorylation of tau and the formation of NFTs, as well as neuron degeneration in AD.
Journal ArticleDOI
Brain MR: Pathologic Correlation with Gross and Histopathology. 2. Hyperintense White-Matter Foci in the Elderly
Bruce H. Braffman,Robert A. Zimmerman,John Q. Trojanowski,Nicholas K. Gonatas,William F. Hickey,William W. Schlaepfer +5 more
TL;DR: Data suggest that subtle changes of gliosis and demyelination, presumably from chronic vascular insufficiency, and/or frank infarction account for the majority of hyperintense white-matter lesions seen in MR in elderly patients.
Journal ArticleDOI
Mutations in COQ2 in familial and sporadic multiple-system atrophy the multiple-system atrophy research collaboration
Jun Mitsui,Takashi Matsukawa,Hiroyuki Ishiura,Yoko Fukuda,Yoko Fukuda,Yaeko Ichikawa,Hidetoshi Date,Budrul Ahsan,Yasuo Nakahara,Yoshio Momose,Yuji Takahashi,Atsushi Iwata,Jun Goto,Yorihiro Yamamoto,Makiko Komata,Katsuhiko Shirahige,Kenju Hara,Akiyoshi Kakita,Mitsunori Yamada,Hitoshi Takahashi,Osamu Onodera,Masatoyo Nishizawa,Hiroshi Takashima,Ryozo Kuwano,Hirohisa Watanabe,Mizuki Ito,Gen Sobue,Hiroyuki Soma,Ichiro Yabe,Hidenao Sasaki,Masashi Aoki,Kinya Ishikawa,Hidehiro Mizusawa,Kazuaki Kanai,Takamichi Hattori,Satoshi Kuwabara,Kimihito Arai,Shigeru Koyano,Yoshiyuki Kuroiwa,Kazuko Hasegawa,Tatsuhiko Yuasa,Kenichi Yasui,Kenji Nakashima,Hijiri Ito,Yuishin Izumi,Ryuji Kaji,Takeo Kato,Susumu Kusunoki,Yasushi Osaki,Masahiro Horiuchi,Tomoyoshi Kondo,Shigeo Murayama,Nobutaka Hattori,Mitsutoshi Yamamoto,Miho Murata,Wataru Satake,Tatsushi Toda,Alexandra Durr,Alexis Brice,Alessandro Filla,Thomas Klockgether,Ullrich Wallner,Garth A. Nicholson,Sid Gilman,Clifford W. Shults,Caroline M. Tanner,Walter A. Kukull,Virginia M.-Y. Lee,Eliezer Masliah,Phillip A. Low,Paola Sandroni,John Q. Trojanowski,Laurie J. Ozelius,Tatiana Foroud,Shoji Tsuji +74 more
TL;DR: Functionally impaired variants of COQ2 were associated with an increased risk of multiple-system atrophy in multiplex families and patients with sporadic disease, providing evidence of a role of impaired COQ1 activities in the pathogenesis of this disease.
Journal ArticleDOI
APOE ε4 increases risk for dementia in pure synucleinopathies.
Debby W. Tsuang,James B. Leverenz,Oscar L. Lopez,Ronald L. Hamilton,David A. Bennett,Julie A. Schneider,Aron S. Buchman,Eric B. Larson,Eric B. Larson,Paul K. Crane,Jeffrey Kaye,Patricia L. Kramer,Randy Woltjer,John Q. Trojanowski,Daniel Weintraub,Daniel Weintraub,Alice Chen-Plotkin,David J. Irwin,Jacqueline Rick,Gerard D. Schellenberg,G. Stennis Watson,Walter A. Kukull,Peter T. Nelson,Gregory A. Jicha,Janna H. Neltner,Doug R. Galasko,Eliezer Masliah,Joseph F. Quinn,Kathryn A. Chung,Dora Yearout,Ignacio F. Mata,Jia Y. Wan,Karen L. Edwards,Thomas J. Montine,Cyrus P. Zabetian +34 more
TL;DR: The elevated ϵ4 frequency in the pDLB and PDD groups, in which the overall brain neuritic plaque burden was low, indicates that apoE might contribute to neurodegeneration through mechanisms unrelated to amyloid processing.
Journal ArticleDOI
Frontotemporal dementia and its subtypes: a genome-wide association study
Raffaele Ferrari,Raffaele Ferrari,Dena G. Hernandez,Dena G. Hernandez,Mike A. Nalls,Jonathan D. Rohrer,Adaikalavan Ramasamy,Adaikalavan Ramasamy,John B.J. Kwok,John B.J. Kwok,Carol Dobson-Stone,Carol Dobson-Stone,William S. Brooks,William S. Brooks,Peter R. Schofield,Peter R. Schofield,Glenda M. Halliday,Glenda M. Halliday,John R. Hodges,John R. Hodges,Olivier Piguet,Olivier Piguet,Lauren Bartley,Elizabeth Thompson,Elizabeth Thompson,Eric Haan,Eric Haan,Isabel Hernández,Agustín Ruiz,Mercè Boada,Barbara Borroni,Alessandro Padovani,Carlos Cruchaga,Nigel J. Cairns,Luisa Benussi,Giuliano Binetti,Roberta Ghidoni,Gianluigi Forloni,Daniela Galimberti,Chiara Fenoglio,Maria Serpente,Elio Scarpini,Jordi Clarimón,Alberto Lleó,Rafael Blesa,Maria Landqvist Waldö,Karin Nilsson,Christer Nilsson,Ian R. A. Mackenzie,Ging-Yuek Robin Hsiung,David M. A. Mann,Jordan Grafman,Jordan Grafman,Jordan Grafman,Christopher Morris,Johannes Attems,Timothy D. Griffiths,Ian G. McKeith,Alan J. Thomas,Pietro Pietrini,Edward D. Huey,Eric M. Wassermann,Atik Baborie,Evelyn Jaros,Evelyn Jaros,Michael Tierney,Pau Pastor,Cristina Razquin,Sara Ortega-Cubero,Elena Alonso,Robert Perneczky,Robert Perneczky,Janine Diehl-Schmid,Panagiotis Alexopoulos,Alexander Kurz,Innocenzo Rainero,Elisa Rubino,Lorenzo Pinessi,Ekaterina Rogaeva,Peter St George-Hyslop,Peter St George-Hyslop,Giacomina Rossi,Fabrizio Tagliavini,Giorgio Giaccone,James B. Rowe,James B. Rowe,Johannes C. M. Schlachetzki,Johannes C. M. Schlachetzki,James Uphill,John Collinge,Simon Mead,Adrian Danek,Adrian Danek,Vivianna M. Van Deerlin,Murray Grossman,John Q. Trojanowski,Julie van der Zee,William Deschamps,Tim Van Langenhove,Marc Cruts,Christine Van Broeckhoven,Stefano F. Cappa,Isabelle Le Ber,Didier Hannequin,Véronique Golfier,Martine Vercelletto,Alexis Brice,Benedetta Nacmias,Sandro Sorbi,Silvia Bagnoli,Irene Piaceri,Jørgen E. Nielsen,Jørgen E. Nielsen,Lena E. Hjermind,Lena E. Hjermind,Matthias Riemenschneider,Manuel Mayhaus,Bernd Ibach,Gilles Gasparoni,Sabrina Pichler,Wei Gu,Wei Gu,Martin N. Rossor,Nick C. Fox,Jason D. Warren,Maria Grazia Spillantini,Huw R. Morris,Patrizia Rizzu,Peter Heutink,Julie S. Snowden,Sara Rollinson,Anna Richardson,Alexander Gerhard,Amalia C. Bruni,Raffaele Maletta,Francesca Frangipane,Chiara Cupidi,Livia Bernardi,Maria Anfossi,Maura Gallo,Maria Elena Conidi,Nicoletta Smirne,Rosa Rademakers,Matthew C. Baker,Dennis W. Dickson,Neill R. Graff-Radford,Ronald C. Petersen,David S. Knopman,Keith A. Josephs,Bradley F. Boeve,Joseph E. Parisi,William W. Seeley,Bruce L. Miller,Anna Karydas,Howard J. Rosen,John C. van Swieten,John C. van Swieten,Elise G.P. Dopper,Harro Seelaar,Yolande A.L. Pijnenburg,Philip Scheltens,Giancarlo Logroscino,Rosa Capozzo,Valeria Novelli,Annibale Alessandro Puca,Massimo Franceschi,Alfredo Postiglione,Graziella Milan,Paolo Sorrentino,Mark Kristiansen,Huei-Hsin Chiang,Caroline Graff,Florence Pasquier,Adeline Rollin,Vincent Deramecourt,Florence Lebert,Dimitrios Kapogiannis,Luigi Ferrucci,Stuart Pickering-Brown,Andrew B. Singleton,John Hardy,Parastoo Momeni +181 more
TL;DR: The findings suggest that immune system processes (link to 6p21.3) and possibly lysosomal and autophagy pathways ( link to 11q14) are potentially involved in FTD.