J
John Q. Trojanowski
Researcher at University of Pennsylvania
Publications - 1538
Citations - 245534
John Q. Trojanowski is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Dementia & Alzheimer's disease. The author has an hindex of 226, co-authored 1467 publications receiving 213948 citations. Previous affiliations of John Q. Trojanowski include Vanderbilt University & University of California, San Francisco.
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Aggregation of Neurofilament and α-Synuclein Proteins in Lewy Bodies: Implications for the Pathogenesis of Parkinson Disease and Lewy Body Dementia
TL;DR: Ulastructural examination of Lewy bodies has revealed masses of aggregated 7-to 25-nm-diameter filaments that appear similar to neurofilaments (NFs), but the precise molecular composition of LBs, including the abnormal filaments in these intracytoplasmic neuronal inclusions, remains to be clarified.
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Understanding disease progression and improving Alzheimer's disease clinical trials: Recent highlights from the Alzheimer's Disease Neuroimaging Initiative
Dallas P. Veitch,Michael W. Weiner,Paul S. Aisen,Laurel A. Beckett,Nigel J. Cairns,Robert C. Green,Danielle J Harvey,Clifford R. Jack,William J. Jagust,John C. Morris,Ronald C. Petersen,Andrew J. Saykin,Leslie M. Shaw,Arthur W. Toga,John Q. Trojanowski +14 more
TL;DR: Select topics that provide insights into AD progression are discussed and how this knowledge may improve clinical trials are outlined.
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Evidence of multisystem disorder in whole-brain map of pathological TDP-43 in amyotrophic lateral sclerosis.
Felix Geser,Nicholas J. Brandmeir,Linda K. Kwong,Maria Martinez-Lage,Lauren Elman,Leo McCluskey,Sharon X. Xie,Virginia M.-Y. Lee,John Q. Trojanowski +8 more
TL;DR: Findings suggest that ALS does not selectively affect only the pyramidal motor system, but rather is a multisystem neurodegenerative TDP-43 proteinopathy.
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Mouse Model of Multiple System Atrophy α-Synuclein Expression in Oligodendrocytes Causes Glial and Neuronal Degeneration
Ikuru Yazawa,Benoit I. Giasson,Ryogen Sasaki,Bin Zhang,Sonali Joyce,Kunihiro Uryu,John Q. Trojanowski,Virginia M.-Y. Lee +7 more
TL;DR: It is demonstrated that overexpression ofalpha-synuclein in oligodendrocytes of mice results in MSA-like degeneration in the CNS and that alpha-syn nuclein inclusions in oligoderms participate in the degeneration of neurons in Msa.
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Brain MR: pathologic correlation with gross and histopathology. 1. Lacunar infarction and Virchow-Robin spaces.
Bruce H. Braffman,Robert A. Zimmerman,John Q. Trojanowski,Nicholas K. Gonatas,William F. Hickey,William W. Schlaepfer +5 more
TL;DR: MR studies of gross and microscopic pathology of lacunae and dilated Virchow-Robin spaces are useful in correlating MR and pathologic findings, however, changes resulting from the fixation process must be considered when postmortem and in vivo MR findings are correlated.