J
John Q. Trojanowski
Researcher at University of Pennsylvania
Publications - 1538
Citations - 245534
John Q. Trojanowski is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Dementia & Alzheimer's disease. The author has an hindex of 226, co-authored 1467 publications receiving 213948 citations. Previous affiliations of John Q. Trojanowski include Vanderbilt University & University of California, San Francisco.
Papers
More filters
Journal ArticleDOI
Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies.
John E. Duda,Benoit I. Giasson,Qiping Chen,Tamar L. Gur,Howard I. Hurtig,Matthew B. Stern,Steven M. Gollomp,Harry Ischiropoulos,Virginia M.-Y. Lee,John Q. Trojanowski +9 more
TL;DR: It is demonstrated that an anti-3-nitrotyrosine polyclonal antibody stains all of the major hallmark lesions of synucleinopathies including Lewy bodies, Lewy neurites and neuraxonal spheroids, implying that alpha-synuclein is nitrated in pathological lesions.
Journal ArticleDOI
Accumulation of amyloid beta and tau and the formation of neurofilament inclusions following diffuse brain injury in the pig.
Douglas H. Smith,Xiao Han Chen,Masahiro Nonaka,John Q. Trojanowski,Virginia M.-Y. Lee,Kathryn E. Saatman,Matthew J. Leoni,Bai-Nan Xu,John A. Wolf,David F. Meaney +9 more
TL;DR: Results show that this pig model of diffuse brain injury is characterized by accumulations of proteins that also form pathological aggregates in AD and related neurodegenerative diseases.
Journal ArticleDOI
Proposed neuropathological criteria for the post mortem diagnosis of multiple system atrophy.
John Q. Trojanowski,Tamas Revesz +1 more
TL;DR: The MSA Workshop recognized the glial cytoplasmic inclusions composed of filamentous alpha‐synuclein as a defining morphological feature of MSA, and it recommends that widespread GCIs should be a criterion for the definite neuropathological diagnosis of M SA.
Journal ArticleDOI
Typical and atypical pathology in primary progressive aphasia variants.
Edoardo G. Spinelli,Maria Luisa Mandelli,Zachary A. Miller,Miguel A. Santos-Santos,Stephen M. Wilson,Federica Agosta,Lea T. Grinberg,Eric J. Huang,John Q. Trojanowski,Marita Meyer,Maya L. Henry,Giancarlo Comi,Gil D. Rabinovici,Howard J. Rosen,Massimo Filippi,Bruce L. Miller,William W. Seeley,Maria Luisa Gorno-Tempini +17 more
TL;DR: In vivo signatures of pathological diagnosis in a large cohort of patients with primary progressive aphasia (PPA) variants defined by current diagnostic classification are characterized.
Journal ArticleDOI
The role of calpain-mediated spectrin proteolysis in traumatically induced axonal injury.
TL;DR: Findings provide the first direct evidence for focal CMSP in the pathogenesis of generalized/diffuse AI and reveal an initial subaxolemmal involvement prior to induction of a more widespread axoplasmic change indicating a spatial-temporal compartmentalization of the calcium-induced proteolytic process that may be amenable to rapid therapeutic intervention.