John Q. Trojanowski

TL;DR: The present article provides a synopsis of the key findings demonstrating the therapeutic potential of MT-stabilizing drugs in the context of neurodegenerative tauopathies, as well as an overview of the different classes ofMT-st stabilizing compounds.

TL;DR: The data do not exclude a structural defect in NF proteins to account for the accumulation of NFs in these axonal swellings, but the hypotheses being advanced to explain the formation of NF-rich globules and spheroids based on intrinsic alterations of NF proteins must consider that the immunological integrity of disparate NF protein epitopes in different states of phosphorylation is retained.

TL;DR: A novel murine model of Aβ and tau pathologies is developed and a spatiotemporal scheme to stage the emergence and accumulation of NFTs with advancing age is devised, providing new insights into the mechanisms of tAU pathobiology.

TL;DR: The results show that the transition from normal cognition to cognitive impairment, including dementia, occurs frequently and quickly in patients diagnosed with Parkinson disease, and certain clinical and cognitive variables may be useful in predicting progression to Cognitive impairment in PD.

TL;DR: Venous hypertensive encephalopathy resulting from a DAVF should be considered a potentially reversible cause of vascular dementia in patients with progressive cognitive deficits.