J
John Q. Trojanowski
Researcher at University of Pennsylvania
Publications - 1538
Citations - 245534
John Q. Trojanowski is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Dementia & Alzheimer's disease. The author has an hindex of 226, co-authored 1467 publications receiving 213948 citations. Previous affiliations of John Q. Trojanowski include Vanderbilt University & University of California, San Francisco.
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Journal ArticleDOI
Neurodegeneration with Brain Iron Accumulation, Type 1 Is Characterized by α-, β-, and γ-Synuclein Neuropathology
TL;DR: This article showed that α-synuclein (αS) accumulates in Lewy body (LB)-like intraneuronal inclusions, glial inclusions and rare neurofibrillary tangles.
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Autosomal dominant dementia with widespread neurofibrillary tangles
Lee Reed,Robert L. Schelper,Ana Solodkin,Gary W. Van Hoesen,John C. Morris,John Q. Trojanowski,Thomas J. Grabowski,Christopher Talbot,Marie L. Schmidt,Alison Goate,Michelle Wragg +10 more
TL;DR: A Midwestern American pedigree spanning four generations in which 15 individuals were affected by early‐onset dementia with long disease duration, with an autosomal dominant inheritance pattern, and with α‐rich neurofibrillary pathology found in the brain post mortem is presented.
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TDP-43 in Cerebrospinal Fluid of Patients With Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis
Petra Steinacker,Corinna Hendrich,Anne D. Sperfeld,Sarah Jesse,Christine A. F. von Arnim,Stefan Lehnert,Alice Pabst,Ingo Uttner,Hayrettin Tumani,Virginia M.-Y. Lee,John Q. Trojanowski,Hans A. Kretzschmar,Albert C. Ludolph,Manuela Neumann,Markus Otto +14 more
TL;DR: CSF TDP-43 levels in CSF might aid in characterizing subgroups of patients across the ALS and FTLD disease spectrum, and although there is no evidence of pathologically altered Tarpa DNA-binding protein 43 proteins inCSF, TDP’s levels might aid the characterizing of patients within these subgroups.
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Amyotrophic lateral sclerosis and frontotemporal lobar degeneration: a spectrum of TDP-43 proteinopathies.
TL;DR: In this article, the authors reviewed salient findings in the development of a concept of TDP-43 proteinopathy as a novel group of neurodegenerative diseases similar in concept to alpha-synucleinopathies and tauopathies.
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Amyotrophic lateral sclerosis, frontotemporal dementia and beyond: the TDP-43 diseases
TL;DR: It is concluded that the TDP-43 proteinopathies represent a novel class of neurodegenerative disorders akin to α-synucleinopathies and tauopathies, with the concept of ALS and FTLD-U to be widened to a broad clinico-pathological multisystem disease, i.e., TDP -43 proteinopathy.