J
John Q. Trojanowski
Researcher at University of Pennsylvania
Publications - 1538
Citations - 245534
John Q. Trojanowski is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Dementia & Alzheimer's disease. The author has an hindex of 226, co-authored 1467 publications receiving 213948 citations. Previous affiliations of John Q. Trojanowski include Vanderbilt University & University of California, San Francisco.
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Journal ArticleDOI
The cytoskeleton in neurodegenerative diseases
TL;DR: The identification of molecular genetic defects and biochemical alterations in cytoskeletal proteins of human neurodegenerative diseases has facilitated experimental studies and will promote the development of assays of molecules which inhibit abnormal neuronal IF and tau protein inclusions.
Recent publications from the Alzheimer's Disease Neuroimaging Initiative: Reviewing progress toward improved AD clinical trials
Michael W. Weiner,Dallas P. Veitch,Paul S. Aisen,Laurel A. Beckett,Nigel J. Cairns,Robert C. Green,Danielle J Harvey,Clifford R. Jack,William J. Jagust,John C. Morris,Ronald C. Petersen,Andrew J. Saykin,Leslie M. Shaw,Arthur W. Toga,John Q. Trojanowski,Alzheimer’s Disease Neuroimaging Initiative +15 more
TL;DR: The Alzheimer's Disease Neuroimaging Initiative (ADNI) has continued development and standardization of methodologies for biomarkers and has provided an increased depth and breadth of data available to qualified researchers.
Journal ArticleDOI
Age-dependent induction of congophilic neurofibrillary tau inclusions in tau transgenic mice.
Takeshi Ishihara,Bin Zhang,Makoto Higuchi,Yasumasa Yoshiyama,John Q. Trojanowski,Virginia M.-Y. Lee +5 more
TL;DR: In conclusion, overexpression of the smallest human brain tau isoform resulted in late onset and age-dependent formation of congophilic tau inclusions with properties similar to those in the tangles of human tauopathies, thereby implicating aging in the pathogenesis of fibrous tAU inclusions.
Journal ArticleDOI
A platform for discovery: The University of Pennsylvania Integrated Neurodegenerative Disease Biobank
Jon B. Toledo,Vivianna M. Van Deerlin,Edward B. Lee,EunRan Suh,Young Baek,John L. Robinson,Sharon X. Xie,Jennifer D. McBride,Elisabeth M. Wood,Theresa Schuck,David J. Irwin,Rachel G. Gross,Howard I. Hurtig,Leo McCluskey,Lauren Elman,Jason Karlawish,Gerard D. Schellenberg,Alice Chen-Plotkin,David A. Wolk,Murray Grossman,Steven E. Arnold,Leslie M. Shaw,Virginia M.-Y. Lee,John Q. Trojanowski +23 more
TL;DR: This work describes a biobanking system that is a platform for discovery research at the Center for Neurodegenerative Disease Research at the University of Pennsylvania and describes a flexible and user‐friendly database system that facilitates the sharing of information of all the teams in the network.
Journal ArticleDOI
Distribution patterns of tau pathology in progressive supranuclear palsy
Gabor G. Kovacs,Gabor G. Kovacs,Gabor G. Kovacs,Milica Ječmenica Lukić,Milica Ječmenica Lukić,David J. Irwin,Thomas Arzberger,Gesine Respondek,Gesine Respondek,Gesine Respondek,Edward B. Lee,David G. Coughlin,David G. Coughlin,Armin Giese,Murray Grossman,Carolin Kurz,Carolin Kurz,Corey T. McMillan,Ellen Gelpi,Ellen Gelpi,Yaroslau Compta,John C. van Swieten,Laura Donker Laat,Claire Troakes,Safa Al-Sarraj,John L. Robinson,Sigrun Roeber,Sharon X. Xie,Virginia M.-Y. Lee,John Q. Trojanowski,Günter U. Höglinger +30 more
TL;DR: Defining cell-specific stages of tau pathology helps to identify preclinical or early-stage cases for the better understanding of early pathogenic events, has implications for understanding the clinical subtype-specific dynamics of disease-propagation, and informs tau-neuroimaging on distribution patterns.